CAS No. 2289690-31-7
Batch:
Purity:99.91
Chemical Structure
Check the
MYCi361
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[3,5-bis(trifluoromethyl)phenyl]-3-[(4-chlorophenyl)methoxy]-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yl]phenol | |
|---|---|---|
| CAS Number | 2289690-31-7 | |
| Molecular Formula |
C26H16ClF9N2O2 |
|
| Molecular Weight (MW) | 594.86 | |
| SMILES | CN1C(=CC(=N1)C(F)(F)F)C2=C(C(=C(C=C2)OCC3=CC=C(C=C3)Cl)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)O | |
| InChIKey | CKLCWLSEYDDTCN-UHFFFAOYSA-N |
MYCi361 is a small-molecule MYC inhibitor that directly engages MYC with a Kd of. Treatment with MYCi361 disrupts MYC/MAX dimerization, downregulates MYC-driven transcription, and destabilizes MYC protein inside cells. Consequently, MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, and upregulates PD-L1 expression on cancer cells, ultimately sensitizing tumors to anti-PD-1 immunotherapy. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(168.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.