CAS No. 2929308-79-0
Batch:
Purity:99.84
Chemical Structure
Check the
MY-1B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R,3S)-3-(4-bromophenyl)-1-prop-2-enoyl-N-quinolin-8-ylazetidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2929308-79-0 | |
| Molecular Formula |
C22H18BrN3O2 |
|
| Molecular Weight (MW) | 436.30 | |
| InChIKey | DXMLBCROCLGUDK-DYESRHJHSA-N |
Biological Activity
MY-1B is a covalent inhibitor of the RNA methyltransferase NSUN2 that stereoselectively targets the active-site cysteine residue C271. By blocking NSUN2-mediated cytosine-5 RNA methylation, MY-1B suppresses post-transcriptional RNA modification pathways. Targeted inhibition of NSUN2 methyltransferase activity alters downstream cellular phenotypes, including RNA stability, protein translation efficiency, and stem cell self-renewal dynamics involved in cell fate regulation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.