CAS No. 1199944-04-1
Batch:
Purity:99.01
Chemical Structure
Check the
MV1035
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methyl-3-propylimidazo[1,2-c][1,3]benzoxazine-5-thione | |
|---|---|---|
| CAS Number | 1199944-04-1 | |
| Molecular Formula |
C14H14N2OS |
|
| Molecular Weight (MW) | 258.34 | |
| InChIKey | OEWGFBGGWFYYNM-UHFFFAOYSA-N |
MV1035 is an imidazobenzoxazin-5-thione inhibitor targeting the RNA demethylase ALKBH5 and the DNA repair protein ALKBH2. Inhibition of ALKBH5 by MV1035 increases N6-methyladenosine levels and downregulates downstream CD73 protein expression, thereby significantly suppressing glioblastoma U87-MG cell migration and invasiveness. Furthermore, MV1035 inhibits ALKBH2 activity and reduces MGMT expression, acting synergistically with temozolomide to decrease cell viability and sphere formation in glioma stem cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(154.83 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.