CAS No. 1421372-66-8

Batch: Purity:99.91
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Mutated EGFR-IN-1 Chemical Structure
Chemical Structure
Check the Mutated EGFR-IN-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1421372-66-8
Molecular Formula

C25H31N7O
Molecular Weight (MW) 445.56
SMILES COC1=C(NC2=NC=CC(=N2)C3=C[N](C)C4=CC=CC=C34)C=C(N)C(=C1)N(C)CCN(C)C

Biological Activity

Mutated EGFR-IN-1 (Osimertinib analog) is a synthetic intermediate and structural analog used in the design and development of inhibitors targeting mutated epidermal growth factor receptor (EGFR) forms, including LR, Exondeletion, and T790M resistance mutants. By serving as a precursor for mutant-selective EGFR kinase inhibitors, it enables the blockade of oncogenic EGFR signaling pathways, suppressing downstream cell proliferation and oncogenesis in resistant non-small cell lung cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Finlay MR, et al. J Med Chem. 2014;57(20):8249-67.

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Note: Technical data last updated: Sep 1, 2026.