CAS No. 445222-91-3
Batch:
Purity:98.72
Chemical Structure
Check the
MuRF1-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-amino-1'-methyl-2',5-dioxospiro[7,8-dihydro-6H-chromene-4,3'-indole]-3-carbonitrile | |
|---|---|---|
| CAS Number | 445222-91-3 | |
| Molecular Formula |
C18H15N3O3 |
|
| Molecular Weight (MW) | 321.33 | |
| SMILES | CN1C(=O)C2(C3=C1C=CC=C3)C(=C(N)OC4=C2C(=O)CCC4)C#N | |
| InChIKey | VXTHFLXWLSPJSP-UHFFFAOYSA-N |
MuRF1-IN-1 is a muscle ring finger protein-1 (MuRF1) inhibitor that disrupts the interaction between MuRF1 and titin to block ubiquitin E3 ligase activity. By modulating the ubiquitin-proteasome pathway, MuRF1-IN-1 inhibits myofibrillar protein degradation and preserves myotube structure. Downstream, this targeted inhibition attenuates skeletal muscle atrophy and prevents contractile dysfunction in mouse models of cardiac cachexia. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.