CAS No. 115074-43-6

Batch: Purity:99.3
Check CoA
Mupirocin calcium Chemical Structure
Chemical Structure
Check the Mupirocin calcium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 115074-43-6
Molecular Formula

C52H86CaO18·2H2O
Molecular Weight (MW) 1075.34
SMILES CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)[O-])C)C(C)O.CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)[O-])C)C(C)O.O.O.[Ca+2]

Biological Activity

Mupirocin calcium is a natural crotonic acid derivative and antibacterial agent that selectively targets bacterial isoleucyl-tRNA synthetase. By reversibly binding to the active site of isoleucyl-tRNA synthetase, it inhibits isoleucyl-tRNA formation and blocks the transfer of isoleucine to nascent peptides. This inhibition disrupts bacterial protein synthesis and arrests cell growth in susceptible Gram-positive pathogens. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (92.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water 6 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Phys. Bull. 1976;27(11):521-521.

Jump to

Note: Technical data last updated: Sep 1, 2026.