CAS No. 1952236-05-3

Batch: Purity:99.56
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MTX-211 Chemical Structure
Chemical Structure
Check the MTX-211 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-chloro-5-[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]-3-pyridinyl]methanesulfonamide
CAS Number 1952236-05-3
Molecular Formula

C20H14Cl2FN5O2S
Molecular Weight (MW) 478.33
SMILES CS(=O)(=O)NC1=C(N=CC(=C1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)Cl
InChIKey GUYKCXXNIKKSBC-UHFFFAOYSA-N

Ordering Information

Biological Activity

MTX-211 is a dual inhibitor targeting phosphoinositide 3-kinase (PI3K) and epidermal growth factor receptor (EGFR) kinase. By concurrently blocking PI3K and EGFR signaling, it suppresses downstream AKT/mTOR and MAPK/ERK pathways, thereby inhibiting cell proliferation and inducing apoptosis in cancer cells. Concurrent targeting of EGFR and PI3K crosstalk represents an effective strategy to overcome signaling resistance in receptor tyrosine kinase-driven malignancies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 48 mg/mL (100.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.