CAS No. 468747-17-3
Batch:
Purity:99.56
Chemical Structure
Check the
mTOR inhibitor-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-bromo-N-[1-(2,4-dihydroxyphenyl)ethylideneamino]-4-methylbenzamide | |
|---|---|---|
| CAS Number | 468747-17-3 | |
| Molecular Formula |
C16H15BrN2O3 |
|
| Molecular Weight (MW) | 363.21 | |
| SMILES | CC1=C(C=C(C=C1)C(=O)NN=C(C)C2=C(C=C(C=C2)O)O)Br | |
| InChIKey | NKMSVTGHOVMMHV-UHFFFAOYSA-N |
mTOR inhibitor-1 is a synthetic small-molecule inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway. By targeting the AKT/mTOR pathway, this compound suppresses cell proliferation and promotes autophagy in various cell types. Inhibition of mTOR signaling downregulates protein synthesis, nutrient sensing, and cellular growth while promoting autophagic flux as a cellular response to metabolic regulation. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.