CAS No. 2332820-04-7
Batch:
Purity:99.32
Chemical Structure
Check the
MTB-9655
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | methyl 3-[4-[[3-(1,1-difluoroethyl)phenyl]carbamoyl]-3-methyl-5-oxo-4H-pyrazol-1-yl]benzoate | |
|---|---|---|
| CAS Number | 2332820-04-7 | |
| Molecular Formula |
C21H19F2N3O4 |
|
| Molecular Weight (MW) | 415.39 | |
| InChIKey | CYQWPQYTOFVAIL-UHFFFAOYSA-N |
Biological Activity
MTB-is a potent and selective inhibitor of acetyl-CoA synthetase 2 (ACSS2). Inhibition of ACSS2 blocks the enzymatic conversion of acetate into acetyl-CoA, thereby disrupting cellular lipid biosynthesis and histone acetylation. Consequently, this metabolic disruption impairs cancer cell survival and suppresses tumor cell proliferation, particularly under hypoxic and nutrient-depleted conditions in the tumor microenvironment. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.