CAS No. 4051-59-6
Batch:
Purity:98.14
Chemical Structure
Check the
MSX-130
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 4051-59-6 | |
|---|---|---|
| Molecular Formula |
C36H26N4 |
|
| Molecular Weight (MW) | 514.62 | |
| SMILES | C1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=C(C=C3)C4=NC(=C(N4)C5=CC=CC=C5)C6=CC=CC=C6)C7=CC=CC=C7 |
MSX-130 is a small-molecule antagonist targeting C-X-C chemokine receptor type 4 (CXCR4). By binding to CXCR4, it inhibits CXCL12-induced chemokine receptor activation and disrupts downstream intracellular signaling cascades, including the AKT and ERK pathways. This functional blockade suppresses CXCR4-mediated cell chemotaxis, directional migration, and metastatic invasion in tumor cell models while modulating microenvironmental chemokine signaling dynamics. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(5.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.