CAS No. 6616-56-4
Batch:
Purity:99.7
Chemical Structure
Check the
MSX-127
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 6616-56-4 | |
|---|---|---|
| Molecular Formula |
C16H24N2O4 |
|
| Molecular Weight (MW) | 308.37 | |
| SMILES | C1COCCN1CC2=CC(=C(C=C2O)CN3CCOCC3)O |
Biological Activity
MSX-127 (NSC-23026) is a small-molecule antagonist targeting C-X-C chemokine receptor type 4 (CXCR4). By inhibiting CXCR4 receptor activation, MSX-127 disrupts downstream CXCL12/CXCR4 chemokine-mediated signaling pathways, including intracellular calcium mobilization and downstream AKT phosphorylation cascades. This functional inhibition leads to significantly reduced cancer cell migration, chemotaxis, and invasive phenotypic properties in preclinical cellular models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(201.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.