CAS No. 897657-95-3
Batch:
Purity:99.24
Chemical Structure
Check the
MSX-122
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 897657-95-3 | |
|---|---|---|
| Molecular Formula |
C16H16N6 |
|
| Molecular Weight (MW) | 292.34 | |
| SMILES | C1=CN=C(N=C1)NCC2=CC=C(C=C2)CNC3=NC=CC=N3 |
Biological Activity
MSX-122 is a small molecule and partial antagonist targeting CXCR4 (IC. By selectively inhibiting the CXCL12/CXCR4 signaling pathway, it blocks agonist-induced CXCR4 activation and downstream intracellular signal transduction. This targeted inhibition effectively attenuates CXCR4-mediated cell migration, invasion, and chemotaxis, thereby disrupting essential microenvironmental crosstalk and metastatic cell dissemination within CXCL12-expressing cellular networks. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(10.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
9 mg/mL
(30.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.