CAS No. 368449-04-1
Batch:
Purity:99.68
Chemical Structure
Check the
MST-312
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide | |
|---|---|---|
| CAS Number | 368449-04-1 | |
| Molecular Formula |
C20H16N2O6 |
|
| Molecular Weight (MW) | 380.35 | |
| InChIKey | MIQUEZGHEJGPJB-UHFFFAOYSA-N |
Biological Activity
MST-312 is a chemically modified derivative of epigallocatechin gallate (EGCG) that acts as a telomerase inhibitor. Inhibition of telomerase activity leads to progressive telomere shortening, suppressing proliferative capacity and promoting growth arrest and cellular senescence in cancer cells. In multiple myeloma models, treatment with MST-312 downregulates anti-apoptotic, proliferative, and inflammatory genes including Bcl-2, c-Myc, hTERT, IL-6, and TNF-α while upregulating Bax to induce apoptosis. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.