CAS No. 1883423-59-3
Batch:
Purity:99.94
Chemical Structure
Check the
MSC2530818
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone | |
|---|---|---|
| CAS Number | 1883423-59-3 | |
| Molecular Formula |
C18H17ClN4O |
|
| Molecular Weight (MW) | 340.81 | |
| SMILES | CC1=C2C=C(C=NC2=NN1)C(=O)N3CCCC3C4=CC=C(C=C4)Cl | |
| InChIKey | ODRITQGYYWHQGM-INIZCTEOSA-N |
MSC2530818 is a potent and selective CDK8 inhibitor with an IC50 of. By inhibiting CDK8 kinase activity within the Mediator complex, MSC2530818 disrupts transcriptional regulation and suppresses downstream oncogenic signaling pathways, including Wnt/β-catenin signaling. Consequently, inhibition of CDK8 reduces STAT1 phosphorylation and modulates target gene expression, ultimately suppressing cell proliferation in cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(199.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.