CAS No. 2445185-57-7

Batch: Purity:99.41
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MSC-4381 Chemical Structure
Chemical Structure
Check the MSC-4381 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[2-[5-chloro-2-[(5-ethoxyquinolin-8-yl)sulfonylamino]phenyl]ethynyl]-4-methoxypyridine-2-carboxylic acid
CAS Number 2445185-57-7
Molecular Formula

C26H20ClN3O6S
Molecular Weight (MW) 537.97
InChIKey FNBUZGRPJLEIMO-UHFFFAOYSA-N

Biological Activity

MSC-is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4). By targeting the cytosolic domain of MCT4, it blocks lactate efflux and promotes intracellular lactate accumulation. This disruption of tumor lactate transport and cellular pH modulation suppresses cellular viability in MCT4-expressing cancer cell lines and demonstrates potent antitumor activity in tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (61.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Heinrich T, et al. J Med Chem. 2021;64(16):11904-11933.

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Note: Technical data last updated: Sep 1, 2026.