CAS No. 3060730-06-2
Batch:
Purity:99.81
Chemical Structure
Check the
MS8709
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S,4R)-1-[(2S)-2-[12-[4-[4-[[2-(4,4-difluoropiperidin-1-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino]piperidin-1-yl]butanoylamino]dodecanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 3060730-06-2 | |
| Molecular Formula |
C64H95F2N11O7S |
|
| Molecular Weight (MW) | 1200.57 | |
| InChIKey | CLUWNSLFLMBFKA-RMCUFUCFSA-N |
Biological Activity
MS8709 is a first-in-class G9a/GLP proteolysis targeting chimera (PROTAC) degrader targeting G9a and GLP methyltransferases. It induces G9a/GLP degradation in a concentration-, time-, and ubiquitin-proteasome system-dependent manner without altering G9a/GLP mRNA expression. By selectively degrading G9a/GLP proteins over other methyltransferases, MS8709 suppresses downstream oncogenic signalling and exhibits potent cell growth inhibition in prostate, leukemia, and lung cancer cells compared to parent G9a/GLP inhibitors. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(83.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.