CAS No. 1395084-25-9
| IUPAC Name | 4-[(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-pyridin-2-ylbenzenesulfonamide | |
|---|---|---|
| CAS Number | 1395084-25-9 | |
| Molecular Formula |
C18H17N5O3S |
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| Molecular Weight (MW) | 383.42 | |
| SMILES | CC1=CC(=C(C=C1O)N)N=NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3 | |
| InChIKey | DZTGIRNXWSZBIM-UHFFFAOYSA-N |
MS436 is a selective BET bromodomain inhibitor targeting BRD4(1) (Ki <0.085 μM) and BRD4(2) (Ki 0.34 μM). By binding to the bromodomains of BRD4, MS436 disrupts chromatin interactions and downregulates NF-kB-mediated transcriptional transactivation. This inhibition leads to reduced expression of proinflammatory cytokines, including IL-6 and TNF-α, in activated macrophages, making it a valuable tool for modulating epigenetic transcription and inflammatory signalling pathways.
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Concentration
Volume
Mass
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| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(143.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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