CAS No. 2768610-97-3
Batch:
Purity:98.76
Chemical Structure
Check the
MS41
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 2768610-97-3 | |
|---|---|---|
| Molecular Formula |
C56H70N8O9S |
|
| Molecular Weight (MW) | 1031.27 |
Biological Activity
MS41 is a highly potent and selective PROTAC degrader of eleven-nineteen leukemia (ENL) that recruits the von Hippel–Lindau (VHL) E3 ubiquitin ligase. Selective degradation of ENL disrupts chromatin binding and downregulates oncogenic gene expression, which suppresses leukemia cell proliferation and impairs disease progression in acute leukemia models. These effects highlight ENL depletion as an effective therapeutic strategy for targeting chromatin reader dependencies in MLL-rearranged leukemia. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(96.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.