CAS No. 1831110-54-3
Batch:
Purity:99.15
Chemical Structure
Check the
MS023
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-methyl-N'-[[4-(4-propan-2-yloxyphenyl)-1H-pyrrol-3-yl]methyl]ethane-1,2-diamine | |
|---|---|---|
| CAS Number | 1831110-54-3 | |
| Molecular Formula |
C17H25N3O |
|
| Molecular Weight (MW) | 287.40 | |
| SMILES | CC(C)OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN | |
| InChIKey | FMTVWAGUJRUAKE-UHFFFAOYSA-N |
MS023 is a potent, selective, substrate-competitive type I protein arginine methyltransferase (PRMT) inhibitor targeting PRMT1 (IC50 30 nM), PRMT3 (IC50 119 nM), PRMT4 (IC50 83 nM), PRMT6 (IC50 4 nM), and PRMT8 (IC50 5 nM). By suppressing type I PRMT enzymatic activity, MS023 blocks cellular protein arginine methylation and significantly reduces cellular asymmetric dimethylarginine (ADMA) levels. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(198.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(198.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 29 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(198.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.