CAS No. 63498-32-8
Batch:
Purity:99.50
Chemical Structure
Check the
MS-L6
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-(N'-phenylcarbamimidoyl)sulfanylhexyl N'-phenylcarbamimidothioate;dihydrobromide | |
|---|---|---|
| CAS Number | 63498-32-8 | |
| Molecular Formula |
C20H26N4S2.2BrH |
|
| Molecular Weight (MW) | 548.40 | |
| InChIKey | MZEJAGCYRPPSDU-UHFFFAOYSA-N |
Biological Activity
MS-L6 is a potent oxidative phosphorylation (OXPHOS) inhibitor that targets electron transport chain complex I (ETC-I). By combining the inhibition of NADH oxidation with an uncoupling effect on the mitochondrial respiratory chain, the compound disrupts cellular ATP production and energy metabolism. This inhibition impairs cancer cell survival and proliferation, demonstrating potent antitumor efficacy across OXPHOS-dependent malignant phenotypes. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(171.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 23 mg/mL |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.