CAS No. 2206736-04-9
Batch:
Purity:99.63
Chemical Structure
Check the
MRTX-1257
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile | |
|---|---|---|
| CAS Number | 2206736-04-9 | |
| Molecular Formula |
C33H39N7O2 |
|
| Molecular Weight (MW) | 565.71 | |
| InChIKey | YRYQLVCTQFBRLD-UIOOFZCWSA-N |
MRTX-1257 is a selective, irreversible, covalent, and orally active inhibitor of KRAS G12C. By binding covalently to the cysteine residue of inactive GDP-bound KRAS G12C, it potently disrupts downstream RAS/RAF/MEK/ERK pathway activation. This blockade suppresses KRAS-dependent ERK phosphorylation, impairs cell viability, and induces apoptosis in KRAS G12C-mutant tumor cell lines and xenograft models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(176.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 30 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.