CAS No. 1781882-89-0
Batch:
Purity:99.80
Chemical Structure
Check the
MRT67307 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[[5-cyclopropyl-2-[3-(morpholin-4-ylmethyl)anilino]pyrimidin-4-yl]amino]propyl]cyclobutanecarboxamide;dihydrochloride | |
|---|---|---|
| CAS Number | 1781882-89-0 | |
| Molecular Formula |
C26H36N6O2· xHCl |
|
| Molecular Weight (MW) | 464.6 (free-base) | |
| SMILES | C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5 | |
| InChIKey | ZIKXPHATVRPOQG-UHFFFAOYSA-N |
MRT67307 is a potent dual kinase inhibitor targeting IKKε and TBK1. By blocking IKKε and TBK1 activity, the compound modulates innate immune and inflammatory signaling cascades. Additionally, MRT67307 potently inhibits ULK1 and ULK2, thereby disrupting ULK complex signaling, suppressing autophagic flux, and blocking autophagy in cellular models.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 92 mg/mL |
| DMSO |
100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 10 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.