CAS No. 2803881-11-8
Batch:
Purity:99.01
Chemical Structure
Check the
MRT-2359
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [2-(2,6-dioxopiperidin-3-yl)-3-oxo-1H-isoindol-5-yl]methyl N-[2-fluoro-5-(trifluoromethoxy)phenyl]carbamate | |
|---|---|---|
| CAS Number | 2803881-11-8 | |
| Molecular Formula |
C22H17F4N3O6 |
|
| Molecular Weight (MW) | 495.38 | |
| InChIKey | HNTGMIGBGVFOBT-UHFFFAOYSA-N |
MRT-is a molecular glue degrader of G1 to S phase transition 1 (GSPT1). It recruits GSPT1 to the cereblon (CRBN) E3 ubiquitin ligase complex, promoting ubiquitin-mediated degradation of GSPT1. This depletion disrupts translational termination, leading to global protein synthesis inhibition and potent anti-tumor activity against non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(201.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.