CAS No. 330829-30-6
Batch:
Purity:98.02
Chemical Structure
Check the
MRT 10
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(3-benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide | |
|---|---|---|
| CAS Number | 330829-30-6 | |
| Molecular Formula |
C24H23N3O5S |
|
| Molecular Weight (MW) | 465.52 | |
| SMILES | COC1=C(OC)C(=CC(=C1)C(=O)NC(=S)NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3)OC | |
| InChIKey | KVQVEZQDNHMQJV-UHFFFAOYSA-N |
MRT 10 is an acylthiourea antagonist of Smoothened (Smo) that inhibits ShhN signaling in Shh-light2 cells with an ICof. By blocking Smo receptor activation, MRT 10 abrogates its constitutive activity and represses downstream Hedgehog signaling pathway transduction. This targeted inhibition suppresses Gli-mediated transcription and downstream cellular responses, providing a valuable chemical tool for investigating Hedgehog-driven biological functions and oncogenic signaling mechanisms.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.