CAS No. 475085-57-5

Batch: Purity:99.93
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MRE-269 (ACT-333679) Chemical Structure
Chemical Structure
Check the MRE-269 (ACT-333679) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-ylamino]butoxy]acetic acid
CAS Number 475085-57-5
Molecular Formula

C25H29N3O3
Molecular Weight (MW) 419.52
SMILES CC(C)N(CCCCOCC(=O)O)C1=CN=C(C(=N1)C2=CC=CC=C2)C3=CC=CC=C3
InChIKey OJQMKCBWYCWFPU-UHFFFAOYSA-N

Biological Activity

MRE-269 (ACT-333679) is a highly selective agonist of the human prostaglandin I2 (IP) receptor, exhibiting a binding affinity for the IP receptor that is 130-fold greater than for other prostanoid receptors. Activation of the IP receptor by MRE-269 increases intracellular cyclic AMP levels, leading to downstream vasodilation and suppression of vascular smooth muscle cell proliferation and platelet aggregation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 84 mg/mL (200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kuwano K, et al. J Pharmacol Exp Ther. 2007;322(3):1181-8.

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Note: Technical data last updated: Sep 1, 2026.