CAS No. 1246529-32-7
Batch:
Purity:99.62
Chemical Structure
Check the
MPI-0479605
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-N-cyclohexyl-2-N-(2-methyl-4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine | |
|---|---|---|
| CAS Number | 1246529-32-7 | |
| Molecular Formula |
C22H29N7O |
|
| Molecular Weight (MW) | 407.51 | |
| SMILES | CC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C(=N3)NC5CCCCC5)NC=N4 | |
| InChIKey | OVJBNYKNHXJGSA-UHFFFAOYSA-N |
MPI-0479605 is an ATP-competitive and selective inhibitor of the mitotic kinase Mps1 (IC50 of with greater than 40-fold selectivity over other protein kinases. Inhibition of Mps1 by MPI-0479605 disrupts the spindle assembly checkpoint (SAC), leading to premature mitotic exit, chromosome misalignment, severely abnormal spindle morphology, and induction of cell death in cancer cell lines. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(152.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.