CAS No. 219832-49-2
Batch:
Purity:98.41
Chemical Structure
Check the
MP-A08
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide | |
|---|---|---|
| CAS Number | 219832-49-2 | |
| Molecular Formula |
C27H25N3O4S2 |
|
| Molecular Weight (MW) | 519.64 | |
| SMILES | CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=CC=C2C=NC3=CC=CC=C3N[S](=O)(=O)C4=CC=C(C)C=C4 | |
| InChIKey | FLDBNMYJUMAXDQ-UHFFFAOYSA-N |
MP-A08 is a selective, ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2. By inhibiting sphingosine kinase activity and decreasing intracellular sphingosine-1-phosphate levels, MP-A08 disrupts pro-proliferative signaling pathways and promotes ceramide accumulation. This downstream signaling shift induces mitochondrial-associated apoptosis in cancer cells and reduces both tumor growth and angiogenesis in preclinical mouse xenograft models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(192.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.