Clinical Trials

Numerous clinical trials spanning Early Phase 1 to Phase 4 evaluate moxifloxacin in conditions such as community-acquired bacterial pneumonia, pulmonary tuberculosis, multidrug-resistant tuberculosis, and postpartum hemorrhage, alongside its use as a standard positive control in Phase 1 cardiac safety assessments. Sponsored by diverse commercial entities and non-governmental institutions like Médecins Sans Frontières, these studies currently encompass completed, recruiting, active not recruiting, and terminated recruitment statuses.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06441006 RECRUITING
Tuberculosis, Pulmonary; Tuberculosis, Multidrug-Resistant; Tuberculosis, MDR
University of California, San Francisco
 2025-10-03 PHASE2; PHASE3
NCT07485010 NOT_YET_RECRUITING
Mycobacterium Abscessus Pulmonary Disease; Mycobacterium Abscessus Infection; Non-Tuberculous Mycobacterial (NTM) Infections; Non-Tuberculous Mycobacteria Pulmonary Disease
The University of Queensland
 2027-04 PHASE2
NCT03244072 NOT_YET_RECRUITING
Endophthalmitis
Jason Ahee, M.D.
 2026-06-01 PHASE2; PHASE3
NCT04310930 RECRUITING
Pulmonary Disease Due to Mycobacteria (Diagnosis)
The University of Queensland
 2020-03-02 PHASE2; PHASE3
NCT07595042 NOT_YET_RECRUITING
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2026-10-30 PHASE2
NCT07585461 NOT_YET_RECRUITING
Opportunistic Infections, HIV Related; Disseminated Mycobacterium Avium Complex Infection
Shanghai Public Health Clinical Center
 2026-04-30
NCT05902221 RECRUITING
Infections Joint Prosthetic
Centre Hospitalier Universitaire de Nice
 2024-05-02 PHASE3
NCT06917495 NOT_YET_RECRUITING
Mild Spinal Tuberculosis
Shandong University
 2025-04-05 PHASE2
NCT07779629 NOT_YET_RECRUITING
Brucellosis; Osteoarthritis
The First Affiliated Hospital of Shihezi University
 2026-09-01
NCT05807399 RECRUITING
Pulmonary Tuberculosis; Other Specified Pulmonary Tuberculosis
Michael Hoelscher
 2023-04-14 PHASE2
NCT06253715 RECRUITING
Tuberculosis; Tuberculosis, Pulmonary; Tuberculosis, Lymph Node; Mycobacterium Tuberculosis
Johns Hopkins University
 2025-01-15 PHASE3
NCT02373280 RECRUITING
Helicobacter Infection
Seoul National University Bundang Hospital
 2014-08
NCT06114628 RECRUITING
Pulmonary Tuberculosis
University College, London
 2024-01-09 PHASE2
NCT05766267 ACTIVE_NOT_RECRUITING
Tuberculosis, Pulmonary; Tuberculosis Infection
Centers for Disease Control and Prevention
 2023-11-21 PHASE2; PHASE3
NCT07129629 NOT_YET_RECRUITING
Tuberculosis, Pulmonary; Drug-Susceptible Pulmonary Tuberculosis
Shanghai Pulmonary Hospital, Shanghai, China
 2025-08-20 PHASE2
NCT05398679 RECRUITING
Endocarditis Infective
Fundacion Clinic per a la Recerca Biomédica
 2022-08-17 PHASE4
NCT07760246 NOT_YET_RECRUITING
Healthy
Boehringer Ingelheim
 2026-08-17 PHASE1
NCT07274020 NOT_YET_RECRUITING
Bronchiectasis, Non-Cystic Fibrosis
Assiut University
 2025-12-01 PHASE3
NCT07116915 RECRUITING
COPD
Guangdong Hengrui Pharmaceutical Co., Ltd
 2025-08-11 PHASE1
NCT07708272 ACTIVE_NOT_RECRUITING
Myelofibrosis
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2026-07-30 PHASE1
NCT06081361 ACTIVE_NOT_RECRUITING
Pulmonary Tuberculosis; Rifampicin-resistant Tuberculosis
Beijing Chest Hospital
 2023-12-22 PHASE3
NCT07594847 RECRUITING
Healthy Adult Subject
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
 2026-03-07 PHASE1
NCT07229157 ACTIVE_NOT_RECRUITING
Overweight; Obesity
Amgen
 2025-10-22 PHASE1
NCT06271772 ACTIVE_NOT_RECRUITING
Bacterial Keratitis
University of California, San Francisco
 2024-07-01 PHASE3
NCT05331664 RECRUITING
Rhegmatogenous Retinal Detachment
Massachusetts Eye and Ear Infirmary
 2022-07-25 PHASE4
NCT07513207 COMPLETED
Healthy
Boehringer Ingelheim
 2026-04-22 PHASE1
NCT07305987 RECRUITING
Cataract Extraction
Laboratorios Sophia S.A de C.V.
 2025-10-27 PHASE3
NCT07422298 COMPLETED
Healthy Volunteers
Bristol-Myers Squibb
 2026-02-19 PHASE1
NCT04722978 RECRUITING
Triple Negative Breast Cancer
Sun Yat-Sen University Cancer Center
 2021-04-20 PHASE3
NCT07014735 TERMINATED
Diabetes Type 2; Hyperglycaemia (Diabetic); QT Interval, Variation in; Torsades de Pointes
Richmond Pharmacology Limited
 2023-04-13
NCT07272629 COMPLETED
Cardiac Repolarization; Healthy Volunteers
Sanofi
 2025-12-04 PHASE1
NCT07305831 COMPLETED
Healthy
Merck Sharp & Dohme LLC
 2026-01-22 PHASE1
NCT07394257 RECRUITING
Bacterial Keratitis; Recalcitrant Infectious Keratitis; Corneal Ulcer
Minia University
 2025-10-01
NCT07212803 RECRUITING
Healthy Volunteers; Safety After Oral Intake
University of the Pacific
 2025-11-01 PHASE4
NCT02735707 RECRUITING
Community-acquired Pneumonia, Influenza, COVID-19
UMC Utrecht
 2016-04-11 PHASE3
NCT07162116 RECRUITING
Acute Myeloid Leukemia With FLT3/ITD Mutation
Shijiazhuang Yiling Pharmaceutical Co. Ltd
 2025-07-06 PHASE1
NCT06210269 NOT_YET_RECRUITING
Uncomplicated Acute Appendicitis
Turku University Hospital
 2024-01
NCT05114720 COMPLETED
Breast Cancer
Sun Yat-sen University
 2021-11-11 PHASE3
NCT06200467 COMPLETED
Overweight; Obesity
Boehringer Ingelheim
 2024-03-13 PHASE1
NCT06846866 COMPLETED
Healthy Volunteers
Bristol-Myers Squibb
 2025-02-27 PHASE1
NCT07023029 COMPLETED
Healthy Volunteers; Sickle Cell Disease; Thalassemia
Novo Nordisk A/S
 2025-06-09 PHASE1
NCT06746402 COMPLETED
Healthy Volunteers
Bristol-Myers Squibb
 2025-02-10 PHASE1
NCT05454345 UNKNOWN
Tuberculosis, Pulmonary
First Affiliated Hospital of Zhejiang University
 2022-10-01 PHASE3
NCT05382312 COMPLETED
Tuberculosis
GlaxoSmithKline
 2022-07-26 PHASE2
NCT06837155 COMPLETED
Healthy Volunteers
Taisho Pharmaceutical Co., Ltd.
 2025-03-03 PHASE1
NCT06855264 COMPLETED
Healthy Volunteer
Immunome, Inc.
 2025-02-24 PHASE1
NCT06649942 COMPLETED
Healthy Volunteers - Male and Female
Kaken Pharmaceutical
 2024-10-01 PHASE1
NCT06574828 COMPLETED
Healthy Volunteer
Biogen
 2024-08-29 PHASE1
NCT07559149 COMPLETED
Infected Corneal Ulcers; CXL
Gadjah Mada University
 2024-07-07 PHASE2
NCT06601192 COMPLETED
RSV Infection; QTc Interval
Enanta Pharmaceuticals, Inc
 2024-07-15 PHASE1
NCT06162286 UNKNOWN
Community-acquired Bacterial Pneumonia
Zai Lab (Hong Kong), Ltd.
 2023-11-17 PHASE3
NCT06591845 COMPLETED
Healthy Volunteers
Shanghai Ark Biopharmaceutical Co., Ltd.
 2024-09-25 PHASE1
NCT06589726 COMPLETED
Healthy
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
 2024-09-10 PHASE1
NCT06411860 COMPLETED
Basic Science
Amgen
 2024-09-12 PHASE1
NCT06462326 COMPLETED
Healthy Volunteer
Zai Lab (Hong Kong), Ltd.
 2024-04-16 PHASE1
NCT05400369 COMPLETED
COPD Exacerbation Acute
Daiichi Sankyo
 2022-08-10 PHASE4
NCT06441318 COMPLETED
Healthy Participants
Incyte Corporation
 2024-07-12 PHASE1
NCT07378579 COMPLETED
Healthy Volunteer
Alumis Inc
 2024-06-21 PHASE1
NCT05926466 UNKNOWN
Tuberculosis, Pulmonary; Other Specified Pulmonary Tuberculosis
Michael Hoelscher
 2023-09-21 PHASE2
NCT06107036 COMPLETED
Healthy
Boehringer Ingelheim
 2024-03-06 PHASE1
NCT06070597 COMPLETED
Healthy
Boehringer Ingelheim
 2024-01-25 PHASE1
NCT06310876 COMPLETED
Healthy
Calico Life Sciences LLC
 2024-03-14 PHASE1
NCT06795204 COMPLETED
Anesthesia; Adverse Effect; Cardiac Arrhythmia
Haisco-USA Pharmaceuticals, Inc.
 2024-04-09 PHASE1
NCT04097730 COMPLETED
Keratitis Bacterial
Thomas M. Lietman
 2020-09-24 PHASE3
NCT06194032 COMPLETED
Healthy Participants
AstraZeneca
 2024-02-29 PHASE1
NCT04779242 COMPLETED
Community-acquired Pneumonia; Bacterial Pneumonia
Paratek Pharmaceuticals Inc
 2021-02-25 PHASE3
NCT06107036 Recruiting
Healthy
Boehringer Ingelheim
 2024-03-04 Phase 1
NCT06310876 Recruiting
Healthy
Calico Life Sciences LLC|AbbVie
 2024-03-14 Phase 1
NCT05893862 COMPLETED
Schizophrenia
Merck Sharp & Dohme LLC
 2023-06-26 PHASE1
NCT06785090 COMPLETED
Cataract; Cystoid Macular Edema After Phacoemulsification
Inas Abd
 2023-05-01 PHASE4
NCT02590523 SUSPENDED
Intracameral Antibiotics; Cataract Surgery; Phacoemulsification; Endophthalmitis; Vancomycin; Moxifloxacin
Panhandle Eye Group, LLP
 2023-01 PHASE3
NCT05027893 UNKNOWN
Postoperative Complications; Antibiotic Reaction; Antibiotic Side Effect; Antibiotic Resistant Infection; Antibiotic Resistant Strain; Infection, Bacterial; Infection, Laboratory
University of Novi Sad
 2019-06-07
NCT04856644 UNKNOWN
Tuberculosis, Pulmonary
Kaohsiung Veterans General Hospital.
 2020-01-01 PHASE3
NCT06161220 COMPLETED
Cardiac Repolarization in Healthy Subjects
Impax Laboratories, LLC
 2023-10-30 PHASE1
NCT05924815 COMPLETED
Healthy Participants
Cytokinetics
 2023-05-15 PHASE1
NCT05878522 COMPLETED
Healthy
Pfizer
 2023-05-15 PHASE1
NCT05830071 COMPLETED
Asthma; Chronic Obstructive Pulmonary Disease (COPD)
Chiesi Farmaceutici S.p.A.
 2023-03-29 PHASE1
NCT05924321 COMPLETED
Postpartum Hemorrhage
Ferring Pharmaceuticals
 2023-05-25 PHASE1
NCT05580003 COMPLETED
Healthy
Pfizer
 2022-10-17 PHASE1
NCT06030219 COMPLETED
Healthy Volunteers
University of Houston
 2020-10-12 PHASE1
NCT05927649 COMPLETED
Health Adult Subjects
Biogen
 2023-07-11 PHASE1
NCT07214935 COMPLETED
Healthy
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
 2022-11-08 PHASE1
NCT05804162 COMPLETED
Obesity
Novo Nordisk A/S
 2023-04-12 PHASE1
NCT04750655 COMPLETED
Antibiotic Resistance; Ocular Surface Microbiome; Gut Resistome
University of California, San Francisco
 2021-03-01 PHASE4
NCT05933447 COMPLETED
Healthy
Altavant Sciences GmbH
 2023-05-12 PHASE1
NCT05995444 COMPLETED
Healthy Volunteers
AN2 Therapeutics, Inc
 2023-06-05 PHASE1
NCT04179500 COMPLETED
Tuberculosis, Pulmonary; Tuberculosis, Multidrug-Resistant; Tuberculosis, MDR; Tuberculosis; Drug-Resistant Tuberculosis
Global Alliance for TB Drug Development
 2021-09-16 PHASE2
NCT05867147 COMPLETED
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 2023-04-26 PHASE1
NCT05716854 COMPLETED
Drug-induced QT Prolongation; Pharmacokinetics; Pharmacodynamics
Food and Drug Administration (FDA)
 2023-03-21 PHASE1
NCT05818852 COMPLETED
Pain
Vertex Pharmaceuticals Incorporated
 2023-04-12 PHASE1
NCT02754765 COMPLETED
Tuberculosis, Multidrug-Resistant; Infection, Bacterial; Pulmonary Tuberculoses
Médecins Sans Frontières, France
 2016-12 PHASE3
NCT05905484 COMPLETED
Healthy Volunteer Study
Atea Pharmaceuticals, Inc.
 2023-04-25 PHASE1
NCT05671029 COMPLETED
Healthy Subjects
AiCuris Anti-infective Cures AG
 2022-12-04 PHASE1
NCT05841160 COMPLETED
QT/QTc
Emalex Biosciences Inc.
 2023-03-15 PHASE1
NCT05668936 TERMINATED
Non-alcoholic Steatohepatitis
AstraZeneca
 2023-01-03 PHASE1
NCT05481528 COMPLETED
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men; Hot Flashes; Healthy Volunteers
Bayer
 2022-08-19 PHASE1
NCT04187469 UNKNOWN
Pulmonary Tuberculosis
Fifth Affiliated Hospital, Sun Yat-Sen University
 2020-03-01
NCT04550832 COMPLETED
Infections and Infestations; Pulmonary Tuberculosis
LigaChem Biosciences, Inc.
 2021-10-28 PHASE2
NCT05508776 COMPLETED
Healthy Volunteers; Cardiac Repolarisation
JW Pharmaceutical
 2022-09-16 PHASE1
NCT05566288 COMPLETED
Smoking Cessation
Achieve Life Sciences
 2022-10-17 PHASE1
NCT05162625 UNKNOWN
Endophthalmitis; Open Globe Injury; Moxifloxacin; Post-Traumatic Endophthalmitis
University of Campinas, Brazil
 2021-12-10 PHASE2
NCT05309902 WITHDRAWN
Healthy Volunteers
Takeda
 2022-10-11 PHASE1
NCT02359331 TERMINATED
Helicobacter Infection
Seoul National University Bundang Hospital
 2014-08
NCT05079854 UNKNOWN
Endophthalmitis; Trauma, Corneal
Federal University of São Paulo
 2021-10-01 PHASE4
NCT05355935 COMPLETED
Healthy Volunteer
Insmed Incorporated
 2022-04-27 PHASE1
NCT05387759 COMPLETED
Healthy
Janssen Research & Development, LLC
 2022-05-30 PHASE1
NCT03959566 COMPLETED
Pulmonary Tuberculosis; Other Specified Pulmonary Tuberculosis
Michael Hoelscher
 2021-05-06 PHASE2
NCT04081077 UNKNOWN
Multi-drug Resistant Tuberculosis; Extensively Drug-Resistant Tuberculosis; Pulmonary Tuberculosis
Medecins Sans Frontieres, Netherlands
 2019-08-06 PHASE2; PHASE3
NCT02589782 COMPLETED
Tuberculosis, Multidrug-Resistant; Extensively Drug-Resistant Tuberculosis; Tuberculosis, Pulmonary
Medecins Sans Frontieres, Netherlands
 2017-01 PHASE2; PHASE3
NCT05293171 COMPLETED
Healthy Subjects
BioLineRx, Ltd.
 2021-06-11 PHASE1
NCT02409290 COMPLETED
MDR-TB
IUATLD, Inc
 2016-03 PHASE3
NCT05046132 COMPLETED
Healthy
Rhythm Pharmaceuticals, Inc.
 2021-08-05 PHASE4
NCT04818229 COMPLETED
Autoimmune Diseases
Connect Biopharma Australia Pty Ltd
 2021-06-01 PHASE1
NCT05241535 COMPLETED
Healthy Subjects
Tanabe Pharma America, Inc.
 2022-01-12 PHASE1
NCT05192369 COMPLETED
Healthy Volunteers
Concert Pharmaceuticals
 2022-01-04 PHASE1
NCT04225078 COMPLETED
Healthy Participants
Janssen Research & Development, LLC
 2020-01-17 PHASE1
NCT04966325 COMPLETED
Hyperuricemia; Gout; Qt Interval, Variation in
LG Chem
 2021-09-23 EARLY_PHASE1
NCT05863858 COMPLETED
Helicobacter Pylori Infection; Helicobacter Pylori Infection, Susceptibility to
Iyad Naeem Muhammad, PhD
 2020-06-01 PHASE3
NCT04953923 COMPLETED
Healthy Volunteers
Astex Pharmaceuticals, Inc.
 2021-07-01 PHASE1
NCT04563845 COMPLETED
HIV Infections
ViiV Healthcare
 2020-11-09 PHASE1
NCT04873323 COMPLETED
Healthy Subjects
Taisho Pharmaceutical Co., Ltd.
 2021-06-07 PHASE1
NCT04255277 COMPLETED
Healthy Subjects
Viatris Innovation GmbH
 2020-01-31 PHASE1
NCT04898907 UNKNOWN
Healthy Volunteer
Angion Biomedica Corp
 2021-06 PHASE1
NCT02563327 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2016-01-25 PHASE3
NCT05428683 COMPLETED
Pharmacological Action
Emad Abdel Aal Saliem
 2020-12-03
NCT04281342 COMPLETED
Healthy Subjects
Idorsia Pharmaceuticals Ltd.
 2020-01-14 PHASE1
NCT04214821 UNKNOWN
Endophthalmitis
National University of Malaysia
 2019-09-23 PHASE1; PHASE2
NCT04212429 UNKNOWN
Endophthalmitis Postoperative
National University of Malaysia
 2019-09-23 PHASE1; PHASE2
NCT04819906 COMPLETED
Prolonged QTc Interval
Estetra
 2021-03-09 PHASE1
NCT03338621 COMPLETED
Tuberculosis, Pulmonary; Tuberculosis, Multidrug-Resistant; Tuberculosis, MDR; Tuberculosis; Drug-Resistant Tuberculosis
Global Alliance for TB Drug Development
 2018-07-30 PHASE2; PHASE3
NCT04821063 COMPLETED
Duchenne and Becker Muscular Dystrophy; Polycytemia Vera
Italfarmaco
 2021-04-13 PHASE1
NCT04873570 COMPLETED
Healthy Individuals; Bioequivalence Study
University of Karachi
 2021-05-28 PHASE1
NCT04795479 COMPLETED
Healthy
Corcept Therapeutics
 2021-01-22 PHASE1
NCT06215521 COMPLETED
Healthy
Eli Lilly and Company
 2020-12-15 PHASE1
NCT04560816 COMPLETED
Healthy
Alexion Pharmaceuticals, Inc.
 2020-07-24 PHASE1
NCT04660890 COMPLETED
Healthy
Alexion Pharmaceuticals, Inc.
 2020-12-12 PHASE1
NCT04692623 COMPLETED
Blood Glucose, Low; Hypoglycemia
Shaheed Benazir Bhutto University Sheringal Dir Upper
 2021-03-01 PHASE1
NCT04688632 COMPLETED
Symptomatic Neurogenic Orthostatic Hypertension; nOH
Theravance Biopharma
 2021-01-18 PHASE1
NCT02454205 COMPLETED
Tuberculosis; Multidrug Resistant Tuberculosis; Extensively-drug Resistant Tuberculosis
University of Cape Town
 2015-11-12 PHASE2; PHASE3
NCT01984827 COMPLETED
Diabetes
Richmond Research Institute
 2019-02-10 PHASE1
NCT03609099 UNKNOWN
Community-acquired Pneumonia
David Garcia Cinca
 2019-02-15 PHASE4
NCT04369391 COMPLETED
Schizophrenia
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2020-06-18 PHASE1
NCT02717871 COMPLETED
Keratitis; Infectious Disease (Manifestation)
University Hospital, Geneva
 2016-03 PHASE3
NCT04342273 COMPLETED
Parkinson's Disease
Kyowa Kirin Co., Ltd.
 2020-03-31 PHASE1
NCT04250506 COMPLETED
Healthy
Idorsia Pharmaceuticals Ltd.
 2020-02-28 PHASE1
NCT02410772 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2016-01-25 PHASE3
NCT04126343 TERMINATED
Healthy Study Participants
UCB Biopharma S.P.R.L.
 2019-10-23 PHASE1
NCT02800785 COMPLETED
Appendicitis
University of Washington
 2016-05
NCT04168723 UNKNOWN
Healthy Volunteers
MedDay Pharmaceuticals SA
 2019-11-11 PHASE1
NCT04238195 COMPLETED
TQT Study
Spero Therapeutics
 2020-01-19 PHASE1
NCT05988034 COMPLETED
Electrocardiography
Amgen
 2019-11-08 PHASE1
NCT03363295 COMPLETED
Endophthalmitis; Macula Edema; Cataract
Universidade Federal de Pernambuco
 2017-07-01 PHASE4
NCT04045769 COMPLETED
Healthy
Zydus Therapeutics Inc.
 2019-08-19 PHASE1
NCT04019574 COMPLETED
Healthy
Cara Therapeutics, Inc.
 2019-06-20 PHASE1
NCT03934203 COMPLETED
Healthy
Boehringer Ingelheim
 2019-05-09 PHASE1
NCT03866369 COMPLETED
Healthy Subjects
Inventiva Pharma
 2019-01-17 PHASE1
NCT03868657 COMPLETED
Long QT Syndrome; Hypoglycemia
Signe Torekov
 2019-01-28
NCT03985410 COMPLETED
Acinetobacter Baumannii-calcoaceticus Complex Infections
Entasis Therapeutics
 2019-05-23 PHASE1
NCT05630274 COMPLETED
Healthy
Eli Lilly and Company
 2019-04-16 PHASE1
NCT01936480 TERMINATED
Cardiac Arrhythmias
Massachusetts General Hospital
 2013-10 PHASE4
NCT02839421 UNKNOWN
Aggressive Periodontitis
Facultad Nacional de Salud Publica
 2015-12 PHASE4
NCT05307614 COMPLETED
Bioequivalence
Abbott
 2019-03-27 PHASE1
NCT03832452 COMPLETED
Healthy
Idorsia Pharmaceuticals Ltd.
 2019-02-14 PHASE1
NCT03777761 COMPLETED
Healthy
Seagen Inc.
 2018-12-06 PHASE1
NCT01298336 COMPLETED
Atypical; Mycobacterium, Pulmonary, Tuberculous
Centre Hospitalier Universitaire, Amiens
 2011-03-02 PHASE3
NCT03606057 COMPLETED
Healthy
Janssen Research & Development, LLC
 2018-07-13 PHASE1
NCT03656952 COMPLETED
Healthy
Pfizer
 2018-09-05 PHASE1
NCT03613649 COMPLETED
Electrocardiogram Repolarisation Abnormality; Gonococcal Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2018-09-25 PHASE1
NCT03236961 ACTIVE_NOT_RECRUITING
Acute Appendicitis
Turku University Hospital
 2017-04-03
NCT03564158 COMPLETED
Healthy
Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
 2018-05-01 PHASE1
NCT03657446 COMPLETED
Healthy Subjects
Idorsia Pharmaceuticals Ltd.
 2018-09-18 PHASE1
NCT05016206 COMPLETED
Healthy
Alexion Pharmaceuticals, Inc.
 2018-07-26 PHASE1
NCT03386279 COMPLETED
Healthy Volunteers
Pfizer
 2018-07-02 PHASE1
NCT03577275 COMPLETED
Dyslipidemias
NorthSea Therapeutics B.V.
 2018-06-15 PHASE1
NCT03541564 COMPLETED
Systemic Lupus Erythematosus; Healthy Participants
Bristol-Myers Squibb
 2018-05-30 PHASE1
NCT03494907 COMPLETED
Healthy
Janssen Research & Development, LLC
 2018-04-09 PHASE1
NCT02679573 COMPLETED
Community Acquired Bacterial Pneumonia
Melinta Therapeutics, Inc.
 2016-12-14 PHASE3
NCT03405168 COMPLETED
Advanced Breast Cancer; Antibiotic; Stable Disease With a Trend of Progression
Sun Yat-sen University
 2018-01-01 PHASE2
NCT03510663 COMPLETED
Congestive Heart Failure
Otsuka Pharmaceutical Co., Ltd.
 2018-05-08 PHASE1
NCT02595359 COMPLETED
Endophthalmitis
Universidade Federal de Pernambuco
 2013-01 PHASE2
NCT02680080 COMPLETED
Long QT Syndrome
Tel-Aviv Sourasky Medical Center
 2016-12-01
NCT03657264 COMPLETED
Healthy Volunteers
Guerbet
 2017-08-21 PHASE1
NCT03822520 COMPLETED
Qt Interval, Variation in
Samsung Medical Center
 2017-06-30 PHASE1
NCT04403334 COMPLETED
Cataract Senile; Endophthalmitis; Antibiotic Side Effect; Safety Issues
Peregrine Eye and Laser Institute
 2018-01-02 PHASE4
NCT03432884 COMPLETED
Healthy Volunteers
BeiGene
 2018-01-25 PHASE1
NCT03709927 COMPLETED
Cardiac Repolarization in Healthy Subjects
Nabriva Therapeutics AG
 2018-01-11 PHASE1
NCT03258515 COMPLETED
Solid Tumors
AstraZeneca
 2017-09-06 PHASE1
NCT03021616 TERMINATED
Cardiovascular Diseases
David Grant U.S. Air Force Medical Center
 2017-06-26
NCT02770729 TERMINATED
Endophthalmitis
University of Campinas, Brazil
 2017-01 PHASE3
NCT02342886 COMPLETED
Tuberculosis, Pulmonary, Drug Sensitive; Tuberculosis, Pulmonary, Multi Drug-resistant
Global Alliance for TB Drug Development
 2015-02 PHASE3
NCT02813694 COMPLETED
Community Acquired Pneumonia
Nabriva Therapeutics AG
 2016-08 PHASE3
NCT03187301 COMPLETED
Parkinson's Disease; Off Episodes of Parkinson Disease
Sumitomo Pharma America, Inc.
 2017-08-03 PHASE2
NCT03164109 COMPLETED
Healthy Volunteers; Healthy
Galera Therapeutics, Inc.
 2017-08-18 PHASE1
NCT03162900 COMPLETED
Healthy Volunteers
Pfizer
 2017-06-09 PHASE1
NCT02903836 COMPLETED
Community-Acquired Bacterial Pneumonia (CABP)
Wockhardt
 2016-11-18 PHASE2
NCT02114684 COMPLETED
Recurrent Tuberculosis
Centre for the AIDS Programme of Research in South Africa
 2013-11 PHASE1; PHASE2
NCT03554304 COMPLETED
QT/QTc Interval in Healthy Volunteers
Wockhardt
 2017-02-09 PHASE1
NCT02911870 COMPLETED
Healthy
Novo Nordisk A/S
 2016-09-23 PHASE1
NCT03516630 COMPLETED
Healthy
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2017-03-20 PHASE1
NCT02559310 COMPLETED
Community Acquired Pneumonia
Nabriva Therapeutics AG
 2015-09 PHASE3
NCT02737605 COMPLETED
Healthy
Janssen Research & Development, LLC
 2016-07-01 PHASE1
NCT02833831 COMPLETED
Healthy
Janssen Research & Development, LLC
 2016-06-02 PHASE1
NCT02910635 COMPLETED
Abnormalities, Cardiovascular
Ionis Pharmaceuticals, Inc.
 2016-09-19 PHASE1
NCT02917200 COMPLETED
Healthy Subjects
Da Volterra
 2016-05-11 PHASE1
NCT02924337 COMPLETED
Qt Interval, Variation in
Poxel SA
 2016-09 PHASE1
NCT02785770 COMPLETED
Healthy
Pfizer
 2016-06-29 PHASE1
NCT02651623 COMPLETED
Healthy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2016-01 PHASE1
NCT02816853 COMPLETED
Healthy
Janssen Research & Development, LLC
 2016-05 PHASE1
NCT02735603 COMPLETED
Heart Repolarization
Orexigen Therapeutics, Inc
 2016-04 PHASE1
NCT02637193 COMPLETED
Healthy Subjects
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2015-12 PHASE1
NCT02820311 COMPLETED
Cardiac Repolarization in Healthy Subjects
Mylan Inc.
 2016-05 PHASE1
NCT02980523 COMPLETED
Bacterial Conjunctivitis
Laboratorios Sophia S.A de C.V.
 2015-03 PHASE2
NCT04867980 COMPLETED
Healthy Volunteers
Acerta Pharma BV
 2016-04-01 PHASE1
NCT02787057 COMPLETED
Peritoneal Dialysis Associated Peritonitis
Peking University First Hospital
 2012-11
NCT02658825 COMPLETED
Healthy
Janssen Research & Development, LLC
 2016-01 PHASE1
NCT02650479 COMPLETED
Healthy Adult Male and Female Volunteers
Intarcia Therapeutics
 2016-01 PHASE1
NCT02515045 COMPLETED
Cataract
Carolina Eyecare Physicians, LLC
 2015-01 PHASE4
NCT02515864 COMPLETED
Healthy
Fuji Yakuhin Co., Ltd.
 2015-08 PHASE2
NCT02576119 TERMINATED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2015-10-19 PHASE1
NCT02193776 COMPLETED
Tuberculosis
Global Alliance for TB Drug Development
 2014-10-23 PHASE2
NCT04019652 COMPLETED
Hypertension; Mineralocorticoid Receptor Antagonist
Daiichi Sankyo
 2015-11-19 PHASE1
NCT01874314 WITHDRAWN
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE1
NCT01154959 COMPLETED
Pulmonary Tuberculosis
Tuberculosis Research Centre, India
 2010-02 PHASE3
NCT02581072 COMPLETED
Acne Vulgaris
Novan, Inc.
 2015-10 PHASE1
NCT02537288 COMPLETED
Healthy
Vantia Ltd
 2015-10 PHASE1
NCT02236026 COMPLETED
Healthy
Population Council
 2014-09 PHASE1
NCT02479308 COMPLETED
Healthy
Alkermes, Inc.
 2015-06 PHASE1
NCT02098486 COMPLETED
Cholangitis
Kangbuk Samsung Hospital
 2014-03 PHASE2
NCT02307864 COMPLETED
Healthy
Janssen Scientific Affairs, LLC
 2014-12-04 PHASE1
NCT02164812 COMPLETED
HIV/AIDS
Bristol-Myers Squibb
 2014-07 PHASE1
NCT02436486 COMPLETED
Healthy Volunteers
H. Lundbeck A/S
 2015-05 PHASE1
NCT01968733 COMPLETED
Community-acquired Bacterial Pneumonia
Melinta Therapeutics, Inc.
 2013-11 PHASE3
NCT02344303 COMPLETED
Healthy
Trevena Inc.
 2014-12 PHASE1
NCT02064348 COMPLETED
Diabetes; Healthy
Novo Nordisk A/S
 2014-02-26 PHASE1
NCT02271438 COMPLETED
Healthy
Janssen Research & Development, LLC
 2014-10 PHASE1
NCT02293148 COMPLETED
Anaemia
GlaxoSmithKline
 2014-11-17 PHASE1
NCT02257398 COMPLETED
Infections, Respiratory Tract
GlaxoSmithKline
 2014-10-06 PHASE1
NCT01069900 COMPLETED
Intraabdominal Infections
Bayer
 2010-07-21 PHASE3
NCT01721135 WITHDRAWN
Asthma
GlaxoSmithKline
 2010-09 PHASE1
NCT02807207 COMPLETED
Healthy Subjects
CTI BioPharma
 2014-10 PHASE1
NCT01259141 COMPLETED
Mycoplasma Pneumonia
Capital Medical University
 2010-10
NCT02091310 COMPLETED
Healthy Volunteers
Genfit
 2014-02 PHASE1
NCT02217930 COMPLETED
Qt Interval, Variation in
Wockhardt
 2014-08 PHASE1
NCT02165332 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2014-07 PHASE1
NCT02241759 COMPLETED
Dyslipidaemia
Xention Ltd
 2014-08 PHASE1
NCT02152332 COMPLETED
Healthy
Janssen Research & Development, LLC
 2014-07 PHASE1
NCT02176005 COMPLETED
Healthy
Da Volterra
 2014-03 PHASE1
NCT02222324 COMPLETED
Healthy Subjects
Eisai Inc.
 2014-08 PHASE1
NCT01756339 COMPLETED
Community-acquired Bacterial Pneumonia
Melinta Therapeutics, Inc.
 2012-12 PHASE3
NCT01785186 COMPLETED
Tuberculosis, Pulmonary
Michael Hoelscher
 2013-04 PHASE2
NCT02104648 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2014-04 PHASE1
NCT02155205 COMPLETED
QT Interval
Lexicon Pharmaceuticals
 2014-05 PHASE1
NCT02056392 COMPLETED
Solid Tumours
AstraZeneca
 2014-03 PHASE1
NCT02207699 COMPLETED
Healthy Volunteers
Pfizer
 2014-05 PHASE1
NCT02027454 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2014-01 PHASE1
NCT02308748 COMPLETED
Drug-induced QT Prolongation; Pharmacokinetics; Pharmacodynamics
Food and Drug Administration (FDA)
 2014-05 PHASE1
NCT02119091 UNKNOWN
Cardiac Toxicity
Haiyan Li
 2014-04 PHASE1
NCT02117830 COMPLETED
Healthy
Repros Therapeutics Inc.
 2014-04 PHASE1
NCT02040987 COMPLETED
Alzheimer's Disease
AstraZeneca
 2014-01 PHASE1
NCT02084953 COMPLETED
Hepatitis C
Bristol-Myers Squibb
 2014-04 PHASE1
NCT01928693 TERMINATED
Corneal Ulcers
Cornea Consultants Of Nashville
 2013-07 PHASE2
NCT01871701 COMPLETED
Healthy
Seoul National University Hospital
 2012-11 PHASE1
NCT02062203 COMPLETED
Healthy Volunteers
Akebia Therapeutics
 2014-01 PHASE1
NCT01573910 COMPLETED
Bacterial Conjunctivitis
Alcon Research
 2012-05 PHASE3
NCT02661594 COMPLETED
Healthy
Acacia Pharma Ltd
 2013-11 PHASE1
NCT02073084 COMPLETED
Dyslipidemia
Kowa Research Institute, Inc.
 2014-01 PHASE1
NCT02125812 COMPLETED
Aggressive Periodontitis
Facultad Nacional de Salud Publica
 2011-08 PHASE4
NCT01839279 COMPLETED
Spasticity
Acorda Therapeutics
 2013-04 PHASE2
NCT01965431 COMPLETED
Healthy
Boehringer Ingelheim
 2013-10 PHASE1
NCT01986894 COMPLETED
Clinical Pharmacology, Healthy Volunteer Study
Celgene
 2013-10-18 PHASE1
NCT01874561 COMPLETED
Cardiac Conduction and Repolarization
Achieve Life Sciences
 2013-05 PHASE1
NCT02128308 COMPLETED
Healthy
Seoul National University Hospital
 2013-11 PHASE1
NCT03958123 COMPLETED
Prolonged QTc Interval; Pharmacokinetic
Tris Pharma, Inc.
 2013-07-10 PHASE1
NCT01913002 COMPLETED
Healthy
Lexicon Pharmaceuticals
 2013-07 PHASE1
NCT00864383 COMPLETED
Pulmonary Tuberculosis
Global Alliance for TB Drug Development
 2008-01 PHASE3
NCT01487135 COMPLETED
Healthy Subjects; Cardiac Repolarization
FORUM Pharmaceuticals Inc
 2011-12 PHASE1
NCT01756521 COMPLETED
the Effect of Moxifloxacin on QT/QTc Interval
Seoul National University Hospital
 2013-01 PHASE1
NCT01854710 COMPLETED
Healthy Volunteers
Alexza Pharmaceuticals, Inc.
 2013-05 PHASE4
NCT01941446 COMPLETED
Normal Healthy Subjects
Tetraphase Pharmaceuticals, Inc
 2013-03 PHASE1
NCT02616913 COMPLETED
Cardiovascular Abnormalities
Cargill
 2013-03
NCT02243241 COMPLETED
Healthy
Purdue Pharma LP
 2012-11 PHASE1
NCT01536951 COMPLETED
Healthy Participants
Eli Lilly and Company
 2012-02 PHASE1
NCT01756495 COMPLETED
Acute Coronary Syndrome
GlaxoSmithKline
 2013-01-10 PHASE1
NCT00728507 TERMINATED
Tuberculosis
Johns Hopkins University
 2009-11 PHASE2
NCT01498419 COMPLETED
Pulmonary Tuberculosis
Global Alliance for TB Drug Development
 2012-03 PHASE2
NCT01790087 COMPLETED
Healthy
Mast Therapeutics, Inc.
 2013-02 PHASE1
NCT01799356 COMPLETED
Pelvic Inflammatory Disease
Istanbul Bakirkoy Maternity and Children Diseases Hospital
 2010-06 PHASE4
NCT01702376 COMPLETED
Obstetric Labour, Premature
GlaxoSmithKline
 2012-10-03 PHASE1
NCT01762839 COMPLETED
Healthy
Melinta Therapeutics, Inc.
 2012-12-27 PHASE1
NCT01398072 UNKNOWN
Chronic Obstructive Pulmonary Disease (COPD).
University College, London
 2011-12 PHASE3
NCT01296542 COMPLETED
Cataracts
Bucci Laser Vision Institute
 2011-05 PHASE4
NCT00323219 COMPLETED
Cellulitis
University of British Columbia
 2004-01 PHASE3
NCT01049022 COMPLETED
Infections
Bayer
 2010-05 PHASE1
NCT01860703 COMPLETED
Prolonged QTc Interval
ApoPharma
 2012-11 PHASE4
NCT01674218 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2012-09 PHASE1
NCT02322619 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2012-11 PHASE1
NCT01689116 COMPLETED
Healthy Volunteers
Biogen
 2012-08-31 PHASE1
NCT02206204 COMPLETED
Cardiodynamics; Safety; Tolerability; Pharmacokinetics
Actelion
 2012-06 PHASE1
NCT02016157 COMPLETED
Chronic Generalized Periodontitis
Sri Hasanamba Dental College and Hospital
 2011-09 PHASE4
NCT01643889 COMPLETED
Healthy
Janssen Research & Development, LLC
 2012-07 PHASE1
NCT01999114 COMPLETED
ECG Effects
Purdue Pharma LP
 2012-03 PHASE1
NCT00458900 COMPLETED
Pneumonia
University Hospital, Ghent
 2007-07 PHASE2
NCT01876316 COMPLETED
Healthy
Inje University
 2011-11
NCT01653990 UNKNOWN
QT Interval Prolongation
Peking University Third Hospital
 2012-07
NCT01859702 COMPLETED
Cataract
Alcon Research
 2012-04 PHASE4
NCT01603030 UNKNOWN
Eye Infection/Inflammation Other
Adapt Produtos Oftalmológicos Ltda.
 2012-06 PHASE3
NCT01606436 COMPLETED
Schizophrenic Disorders
Denovo Biopharma LLC
 2012-06 PHASE1
NCT01552928 COMPLETED
Healthy
Shire
 2012-03-29 PHASE1
NCT01055145 TERMINATED
TB
Seoul National University Hospital
 2010-03 PHASE3
NCT01521377 COMPLETED
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline
 2011-12-19 PHASE1
NCT01928914 COMPLETED
Malaria, Vivax
GlaxoSmithKline
 2011-07-26 PHASE1
NCT01565720 COMPLETED
Pharmacokinetics of Isavuconazole; Healthy Volunteers
Astellas Pharma Global Development, Inc.
 2012-03 PHASE1
NCT01537887 COMPLETED
Healthy Volunteers
Eli Lilly and Company
 2012-02 PHASE1
NCT02223702 COMPLETED
Generalized Aggressive Periodontitis; Aggressive Periodontitis
Kocaeli University
 2011-05 PHASE4
NCT01518699 COMPLETED
Pediculosis
Dr. Reddy's Laboratories Limited
 2012-01 PHASE1
NCT01359618 TERMINATED
Healthy Male
AstraZeneca
 2011-06 PHASE1
NCT01516372 COMPLETED
Restless Legs Syndrome
XenoPort, Inc.
 2012-01 PHASE1
NCT01460368 COMPLETED
Diabetes Mellitus, Type 2
Eli Lilly and Company
 2011-10 PHASE1
NCT01376076 COMPLETED
Schizophrenia
Forest Laboratories
 2011-06 PHASE1
NCT01423916 COMPLETED
Schizophrenia; Schizoaffective Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2011-07 PHASE1
NCT02136888 COMPLETED
Healthy
Actelion
 2011-08 PHASE1
NCT01406262 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
 2011-07-06 PHASE1
NCT03465436 COMPLETED
Healthy
Eli Lilly and Company
 2011-09-16 PHASE1
NCT01449188 COMPLETED
Nausea and Vomiting, Chemotherapy-Induced
GlaxoSmithKline
 2011-08-16 PHASE1
NCT01577342 COMPLETED
Age-Related Macular Degeneration
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2010-11
NCT01158755 COMPLETED
Meningitis, Tuberculous; Pharmacokinetics; Pharmacodynamics; Tolerability
Universitas Padjadjaran
 2010-10 PHASE2
NCT01398293 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2011-08 PHASE1
NCT02050802 COMPLETED
Healthy
Actelion
 2011-08 PHASE1
NCT01198626 TERMINATED
Community-Acquired Bacterial Pneumonia (CABP)
Furiex Pharmaceuticals, Inc
 2010-10 PHASE2
NCT01071902 TERMINATED
Acute Otitis Media
Alcon Research
 2010-02 PHASE3
NCT01642485 COMPLETED
Effects of Different Meals on the QT/QTc Interval; Insulin and Oral Hypoglycemic [Antidiabetic] Drugs Causing Adverse Effects in Therapeutic Use; C-Peptide Effects on the QT/QTc Interval; Moxifloxacin ECG Profile in Fed and Fasted State; Japanese vs. Caucasian TQT Comparison
Richmond Pharmacology Limited
 2011-07 PHASE1
NCT00629135 COMPLETED
Abscess, Intra-Abdominal
Hannover Medical School
 2005-11-15 PHASE3
NCT01353729 COMPLETED
Influenza, Human
GlaxoSmithKline
 2011-05-19 PHASE1
NCT01525394 COMPLETED
Refractory Solid Tumors; Lymphomas
Eisai Inc.
 2010-12 PHASE1
NCT01269294 COMPLETED
Hepatitis C
Tibotec Pharmaceuticals, Ireland
 2011-01 PHASE1
NCT01287793 COMPLETED
Healthy
Pfizer
 2011-01 PHASE1
NCT01290900 COMPLETED
Healthy Male Volunteers
Pfizer
 2011-02 PHASE1
NCT01215851 COMPLETED
Pulmonary Tuberculosis
Global Alliance for TB Drug Development
 2010-10 PHASE2
NCT01265641 COMPLETED
Asthma
AstraZeneca
 2011-01 PHASE1
NCT01297062 COMPLETED
Healthy Subjects
AstraZeneca
 2011-02 PHASE1
NCT01327066 COMPLETED
QTc Interval
Chelsea Therapeutics
 2011-03 PHASE1
NCT01173536 COMPLETED
Healthy Volunteer
Genentech, Inc.
 2010-08-25 PHASE1
NCT01232413 COMPLETED
Healthy Subjects; Cardiac Repolarization
Astellas Pharma Inc
 2010-09 PHASE1
NCT01222442 COMPLETED
Chronic Obstructive Pulmonary Disease; Lung Disease
AstraZeneca
 2010-11 PHASE1
NCT01209026 COMPLETED
Asthma
GlaxoSmithKline
 2010-06-23 PHASE1
NCT00887276 TERMINATED
Community Acquired Pneumonia
University of Ulm
 2008-11 PHASE4
NCT01140425 COMPLETED
Healthy
Pfizer
 2010-07 PHASE1
NCT01792700 COMPLETED
Helicobacter Infections
Seoul National University Bundang Hospital
 2003-01 PHASE4
NCT00656747 COMPLETED
Chronic Bronchitis
Bayer
 2008-03 PHASE4
NCT00952796 COMPLETED
Intra-abdominal Infection
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2009-01 PHASE4
NCT01195675 COMPLETED
Healthy
Boehringer Ingelheim
 2010-08 PHASE1
NCT01199523 COMPLETED
Healthy Subjects
Astellas Pharma Inc
 2010-05 PHASE1
NCT01073891 COMPLETED
Healthy
Bayer
 2010-05 PHASE1
NCT00447304 COMPLETED
Acute Cholecystitis
Heidelberg University
 2006-10 PHASE3
NCT01532115 COMPLETED
Parkinson Disease
Bial - Portela C S.A.
 2010-05 PHASE1
NCT01191723 COMPLETED
Healthy
Allergan
 2010-08 PHASE1
NCT01107054 COMPLETED
Pulmonary Disease; Lung Disease; Moxifloxacin
Pfizer
 2010-06 PHASE1
NCT01135680 COMPLETED
Drug Toxicity
Amgen
 2010-05 PHASE1
NCT01039610 WITHDRAWN
Infections, Bacterial
GlaxoSmithKline
 2009-11 PHASE1
NCT01103830 COMPLETED
Malaria, Falciparum
sigma-tau i.f.r. S.p.A.
 2010-02 PHASE1
NCT01302951 COMPLETED
Side-effect of Antibiotic
University Hospital, Saarland
 2008-07 PHASE4
NCT02508753 COMPLETED
Healthy
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
 2010-06 PHASE1
NCT01130922 COMPLETED
Gastric Bypass; Body Weight
University Ghent
 2010-03 PHASE4
NCT01090661 COMPLETED
Healthy
Kastle Therapeutics, LLC
 2010-03 PHASE1
NCT00926263 TERMINATED
Healthy Volunteers
Pfizer
 2009-07 PHASE1
NCT00865280 TERMINATED
Skin Diseases, Infectious
Paratek Pharmaceuticals Inc
 2009-04-04 PHASE3
NCT00978614 COMPLETED
Healthy Subjects
Merz Pharmaceuticals GmbH
 2009-09 PHASE1
NCT00534287 COMPLETED
Severe Sepsis; Septic Shock
Kompetenznetz Sepsis
 2007-10 PHASE3
NCT01017731 COMPLETED
Cancer; Solid Tumor
Eli Lilly and Company
 2009-11 PHASE2
NCT00936871 COMPLETED
Healthy Volunteers
Pfizer
 2010-01 PHASE1
NCT00759148 COMPLETED
Bacterial Conjunctivitis
Alcon Research
 2008-10 PHASE3
NCT00752947 UNKNOWN
Community-Acquired Pneumonia
Beijing Hospital
 2008-09 PHASE4
NCT00861029 COMPLETED
Carcinoma, Renal Cell
GlaxoSmithKline
 2009-03-19 PHASE1
NCT00979316 COMPLETED
Alzheimer Disease
Bristol-Myers Squibb
 2009-09 PHASE1
NCT00973388 COMPLETED
Hepatitis C
Tibotec BVBA
 2009-10 PHASE1
NCT00964730 COMPLETED
Healthy
Teva Branded Pharmaceutical Products R&D, Inc.
 2009-10 PHASE1
NCT00758199 COMPLETED
Cataracts
Bp Consulting, Inc
 2008-07 PHASE4
NCT00805558 COMPLETED
Chronic Periodontitis
Facultad Nacional de Salud Publica
 2009-02 PHASE4
NCT00280514 COMPLETED
Abscess; Cysts
Medical University of Vienna
 2006-01 PHASE4
NCT00996021 COMPLETED
Healthy Subjects
GlaxoSmithKline
 2009-09 PHASE1
NCT00924729 COMPLETED
Cataract Extraction
Johns Hopkins University
 2009-09 PHASE4
NCT00828971 COMPLETED
Infectious Diseases
Bayer
 2008-11 PHASE3
NCT00874887 COMPLETED
Anti-biotic Resistance
Allergan
 2009-03 PHASE4
NCT00840580 COMPLETED
Cataract Extraction
Alcon Research
 2009-01 PHASE4
NCT00914121 COMPLETED
Healthy Subjects
Wyeth is now a wholly owned subsidiary of Pfizer
 2009-06 PHASE1
NCT00884533 WITHDRAWN
Alzheimer's Disease
GlaxoSmithKline
 2009-06 PHASE1
NCT00890565 COMPLETED
Healthy
Kyowa Kirin Co., Ltd.
 2009-05 PHASE1
NCT00809289 COMPLETED
Fibromyalgia
Pfizer
 2008-12 PHASE1
NCT00824070 COMPLETED
Cataract Extraction
Bausch & Lomb Incorporated
 2009-02 PHASE1
NCT01613040 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2009-01 PHASE1
NCT00874237 COMPLETED
Thorough QT/QTc Study
Nova Pneuma Inc.
 2009-04 PHASE1
NCT00717561 COMPLETED
Pneumonia
Bayer
 2008-02 PHASE3
NCT00905762 COMPLETED
Healthy
Bausch & Lomb Incorporated
 2009-03 PHASE1
NCT00850746 COMPLETED
Functional Dyspepsia
Astellas Pharma Inc
 2009-02 PHASE1
NCT00903747 COMPLETED
Constipation
Movetis
 2009-01 PHASE1
NCT00795145 COMPLETED
Bacterial Infections
Pfizer
 2008-12 PHASE1
NCT00581542 COMPLETED
Conjunctivitis
University of Rochester
 2007-03 PHASE4
NCT00764582 TERMINATED
Corneal Transplantation
Santen Inc.
 2008-09 PHASE4
NCT00579020 TERMINATED
Corneal Infiltrates
Alcon Research
 2007-12 PHASE2
NCT00492726 COMPLETED
Infection
Bayer
 2006-07 PHASE3
NCT00870103 COMPLETED
Cataract
Alcon Research
 2008-09 PHASE4
NCT00750633 COMPLETED
Acute Otitis Externa
Alcon Research
 2008-06 PHASE3
NCT00769041 COMPLETED
Erectile Dysfunction
VIVUS LLC
 2008-10 PHASE1
NCT00579189 COMPLETED
Acute Otitis Media
Alcon Research
 2006-01 PHASE3
NCT00744809 COMPLETED
Human Volunteers
Tibotec Pharmaceuticals, Ireland
 2008-08 PHASE1
NCT00789568 COMPLETED
Phenylketonuria
BioMarin Pharmaceutical
 2008-10 PHASE1
NCT00578773 COMPLETED
Acute Otitis Media
Alcon Research
 2007-11 PHASE2
NCT00777595 COMPLETED
Chronic Obstructive Pulmonary Disease
Chiesi Farmaceutici S.p.A.
 2008-10 PHASE1
NCT00398411 COMPLETED
Hodgkin Disease; Non-Hodgkin Lymphoma; Multiple Myeloma; Bacteremia
University of Cologne
 2006-10 PHASE3
NCT00699504 COMPLETED
Healthy
The Medicines Company
 2008-06 PHASE1
NCT02182310 COMPLETED
Healthy
Boehringer Ingelheim
 2008-06 PHASE1
NCT00630019 COMPLETED
Cataract
Santen Inc.
 2008-02 PHASE4
NCT00575367 COMPLETED
Bacterial Infections; Eye Infections
Merck Sharp & Dohme LLC
 2008-03 PHASE4
NCT00675701 COMPLETED
Healthy
CardioKine Inc.
 2008-05 PHASE1
NCT01787357 COMPLETED
Healthy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2008-06 PHASE1
NCT00464438 COMPLETED
Bacterial Conjunctivitis
Allergan
 2007-06 PHASE4
NCT00460759 TERMINATED
Mycobacterium Tuberculosis
Johns Hopkins University
 2007-06 PHASE1
NCT00672984 COMPLETED
Healthy Volunteers
Shire
 2008-04-18 PHASE1
NCT01263808 COMPLETED
Healthy Volunteers; Chronic Obstructive Pulmonary Disease
Novartis Pharmaceuticals
 2008-04 PHASE1
NCT00254566 COMPLETED
Chronic Bronchitis
Pfizer
 2006-02 PHASE3
NCT00686179 COMPLETED
Healthy
AstraZeneca
 2008-01 PHASE1
NCT00721344 COMPLETED
Healthy Subjects
Mannkind Corporation
 2008-04 PHASE1
NCT00708903 COMPLETED
Breast Cancer
Puma Biotechnology, Inc.
 2008-05 PHASE1
NCT00672399 COMPLETED
Healthy Subjects
AstraZeneca
 2008-04 PHASE1
NCT00575380 COMPLETED
Bacterial Infections; Eye Infections; Cataract Extraction
Merck Sharp & Dohme LLC
 2007-12 PHASE4
NCT01322139 COMPLETED
Effects of Sativex on ECG
Jazz Pharmaceuticals
 2007-12 PHASE1
NCT00703313 COMPLETED
Healthy
Santen Inc.
 2008-05 PHASE4
NCT02183467 COMPLETED
Healthy
Boehringer Ingelheim
 2008-01 PHASE1
NCT00402727 COMPLETED
Abscess; Wound Infection; Diabetic Foot; Ulcer
Bayer
 2006-09 PHASE3
NCT00453349 COMPLETED
Pelvic Inflammatory Disease
Bayer
 2007-01 PHASE3
NCT00492024 COMPLETED
Sinusitis
Bayer
 2005-01 PHASE3
NCT00532610 COMPLETED
Type 2 Diabetes Mellitus; Diabetes Mellitus, Type 2
GlaxoSmithKline
 2007-09 PHASE1
NCT01018420 COMPLETED
Pharmacokinetics
Mutual Pharmaceutical Company, Inc.
 2007-11 PHASE1
NCT00543062 COMPLETED
Cardiotoxicity
Alexza Pharmaceuticals, Inc.
 2007-10 PHASE1
NCT00396084 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2004-02-10 PHASE1; PHASE2
NCT02262546 COMPLETED
Healthy
Boehringer Ingelheim
 2007-05 PHASE1
NCT00082173 COMPLETED
Tuberculosis
Johns Hopkins University
 2004-10 PHASE2
NCT00485667 COMPLETED
Postoperative Pain
Pacira Pharmaceuticals, Inc
 2007-06 PHASE1
NCT00164463 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2004-07 PHASE2
NCT00348348 COMPLETED
Acute Bacterial Conjunctivitis
Bausch & Lomb Incorporated
 2006-06 PHASE3
NCT00144417 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2006-02 PHASE2
NCT02283788 COMPLETED
Epilepsy
Bial - Portela C S.A.
 2007-03 PHASE1
NCT00324324 TERMINATED
Breast Cancer; Chronic Myeloproliferative Disorders; Gestational Trophoblastic Tumor; Infection; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neuroblastoma; Ovarian Cancer; Testicular Germ Cell Tumor
OHSU Knight Cancer Institute
 2006-05 PHASE3
NCT00419783 COMPLETED
Healthy
Faes Farma, S.A.
 2006-08 PHASE1
NCT00331084 COMPLETED
Inflammation Following Cataract Surgery
Federal University of São Paulo
 2006-04
NCT00332293 COMPLETED
Bacterial Conjunctivitis
Alcon Research
 2006-05 PHASE3
NCT00769171 COMPLETED
Infection, Intra-abdominal
Bayer
 2005-10 PHASE3
NCT00062231 TERMINATED
Chronic Myeloproliferative Disorders; Fever, Sweats, and Hot Flashes; Infection; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neutropenia; Precancerous Condition; Unspecified Adult Solid Tumor, Protocol Specific
European Organisation for Research and Treatment of Cancer - EORTC
 2002-04
NCT00330824 COMPLETED
Post Lasik Surgery Inflammation
Federal University of São Paulo
 2006-04
NCT00292227 COMPLETED
Parkinson's Disease
UCB Pharma
 2006-01 PHASE1
NCT02170987 COMPLETED
Healthy
Boehringer Ingelheim
 2006-03 PHASE1
NCT00306319 COMPLETED
Tuberculosis
Radboud University Medical Center
 2006-01 PHASE2
NCT02248883 COMPLETED
Healthy
Boehringer Ingelheim
 2005-12 PHASE1
NCT02256735 COMPLETED
Healthy
Boehringer Ingelheim
 2005-08 PHASE1
NCT00431678 COMPLETED
Pneumonia
Bayer
 2004-01 PHASE3
NCT00257452 COMPLETED
Healthy
Boehringer Ingelheim
 2004-10 PHASE1
NCT00414011 COMPLETED
Epithelium, Corneal
Walter Reed Army Medical Center
NCT01363323 COMPLETED
Healthy Volunteers
Bausch Health Americas, Inc.
 2004-11 PHASE1
NCT01148537 COMPLETED
Healthy Volunteers
Purdue Pharma LP
 2004-07 PHASE1
NCT00683865 COMPLETED
Pelvic Inflammatory Disease
Bayer
 2003-04 PHASE3
NCT02264015 COMPLETED
Healthy
Boehringer Ingelheim
 2004-01 PHASE1
NCT00665327 COMPLETED
Pneumonia
Bayer
 2002-11 PHASE4
NCT03951402 COMPLETED
Prolonged QTc Interval; Pharmacokinetic
Grünenthal GmbH
 2003-03 PHASE1
NCT00158093 COMPLETED
Hypertension
Mylan Bertek Pharmaceuticals
 2003-06 PHASE1
NCT00887770 COMPLETED
Rheumatoid Arthritis
AstraZeneca
 2009-04 PHASE1
NCT00466570 WITHDRAWN
Conjunctical Flora
Stanford University
 2007-04
NCT00407017 COMPLETED
Cataract Surgery
Innovative Medical
 PHASE4
NCT00335088 UNKNOWN
Eye Infections
HaEmek Medical Center, Israel
 2006-06 PHASE3
NCT00447629 COMPLETED
Diabetes Mellitus
Wyeth is now a wholly owned subsidiary of Pfizer
 2007-01 PHASE1
NCT00437242 TERMINATED
Fibrillation, Atrial; Atrial Fibrillation
GlaxoSmithKline
 2006-10 PHASE1
NCT00411073 COMPLETED
Atherosclerosis
GlaxoSmithKline
 2006-12 PHASE1
NCT00668304 COMPLETED
Maxillary Sinusitis
Bayer
 2004-06 PHASE4
NCT00140309 COMPLETED
Tuberculosis, Pulmonary
Centers for Disease Control and Prevention
 2003-07 PHASE2
NCT00316459 COMPLETED
Healthy; Long QT Syndrome
Wyeth is now a wholly owned subsidiary of Pfizer
 2006-05 PHASE1
NCT00499642 COMPLETED
Alzheimer Disease; Healthy
Wyeth is now a wholly owned subsidiary of Pfizer
 2007-06 PHASE1
NCT00310596 COMPLETED
Healthy
Bayer
 2004-01 PHASE1
NCT00199225 COMPLETED
Human Experimentation (Human Volunteers)
J. Uriach and Company
 2005-02 PHASE1
NCT00434395 COMPLETED
Healthy
Bausch Health Americas, Inc.
 2007-03 PHASE1
NCT00360425 COMPLETED
Anemia
AMAG Pharmaceuticals, Inc.
 2006-05 PHASE1
NCT01045902 COMPLETED
Pneumonia, Aspiration; Lung Abscess
Bayer
 2001-02 PHASE3
NCT00347828 UNKNOWN
Eye Infection; Infection
Ophthalmic Consultants of Boston
 2006-06 PHASE4
NCT01514929 COMPLETED
Cardiac Effects in Normal Healthy Volunteers
Achaogen, Inc.
 2011-10 PHASE1
NCT00455806 UNKNOWN
Helicobacter Pylori Infection; Chronic Gastritis
Technische Universität Dresden
 2007-01 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-09-02)

Check the Moxifloxacin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Moxifloxacin selectively targets and inhibits bacterial DNA gyrase and topoisomerase IV, which blocks essential DNA supercoiling, replication, and transcription processes within susceptible pathogens. This biochemical disruption triggers lethal double-stranded DNA cleavage and rapid bactericidal cell death, conferring direct clinical efficacy against respiratory and mycobacterial infections such as community-acquired bacterial pneumonia and tuberculosis.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.