CAS No. 1402057-88-8
Batch:
Purity:99.21
Chemical Structure
Check the
Monzosertib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl 4-hydroxy-5-[(Z)-pyrrolo[2,3-b]pyridin-3-ylidenemethyl]-2-[[4-(2,2,2-trifluoroethyl)piperazin-1-yl]amino]furan-3-carboxylate | |
|---|---|---|
| CAS Number | 1402057-88-8 | |
| Molecular Formula |
C21H22F3N5O4 |
|
| Molecular Weight (MW) | 465.43 | |
| InChIKey | HFBNZZVVRMLDJO-JLHYYAGUSA-N |
Monzosertib (AS-0141) is a potent, selective, and orally bioavailable inhibitor of cell division cycle 7 (CDC7) kinase. By inhibiting CDC7, it impairs phosphorylation of the MCM complex, suppressing the initiation of DNA replication and triggering cell cycle arrest and apoptosis in tumor cells. Monzosertib exhibits broad antitumor efficacy across preclinical models of hematologic and solid malignancies, including acute myeloid leukemia. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
93 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.