CAS No. 141646-00-6

Batch: Purity:99.92
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Mometasone Furoate Hydrate Chemical Structure
Chemical Structure
Check the Mometasone Furoate Hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 141646-00-6
Molecular Formula

C27H30Cl2O6.H2O
Molecular Weight (MW) 539.45
SMILES O.CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(CC2(C)C1(OC(=O)C5=CC=CO5)C(=O)CCl)OC(=O)C6=CC=CO6

Ordering Information

Biological Activity

Mometasone Furoate Hydrate is a synthetic glucocorticoid that acts as a potent agonist of the glucocorticoid receptor. Activation of the receptor induces expression of anti-inflammatory proteins, such as CD163 in human monocytes. Additionally, mometasone furoate functions as a farnesoid X receptor (FXR) ligand that suppresses NF-kB-mediated transcription of pro-inflammatory cytokines including CXCL2 and IL, thereby inhibiting inflammatory responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (185.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.