CAS No. 15622-65-8

Batch: Purity:99.63
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Molindone hydrochloride Chemical Structure
Chemical Structure
Check the Molindone hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 15622-65-8
Molecular Formula

C16H24N2O2.HCl
Molecular Weight (MW) 312.83
SMILES CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C.Cl

Biological Activity

Molindone hydrochloride is a conventional antipsychotic agent that acts as an antagonist of dopamine D2 and D5 receptors. By selectively blocking central dopamine receptors, it attenuates dopaminergic signal transduction through G protein-coupled receptor pathways. This inhibition reduces downstream cyclic AMP production and modulates dopaminergic neurotransmission in neuronal circuits, contributing to the inhibition of hyperactivity phenotypes in preclinical models of psychosis.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 9 mg/mL (28.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.