CAS No. 352693-80-2
Batch:
Purity:99.03
Chemical Structure
Check the
MMRi62
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol | |
|---|---|---|
| CAS Number | 352693-80-2 | |
| Molecular Formula |
C21H15Cl2N3O |
|
| Molecular Weight (MW) | 396.27 | |
| InChIKey | FMUBUUSODRAEMS-UHFFFAOYSA-N |
Biological Activity
MMRi62 is a ferroptosis inducer that targets the MDM2-MDM4 complex. It promotes lysosomal degradation of ferritin heavy chain and NCOA4, driving increased autophagy and reactive oxygen species accumulation. Additionally, MMRi62 induces proteasomal degradation of mutant p53 and targets MDM4 for degradation, triggering p53-independent cell death, inhibition of cell proliferation, and suppression of tumor growth and metastasis. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.