CAS No. 16616-39-0
Batch:
Purity:99.81
Chemical Structure
Check the
MLS000532223
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one | |
|---|---|---|
| CAS Number | 16616-39-0 | |
| Molecular Formula |
C15H9NO3 |
|
| Molecular Weight (MW) | 251.24 | |
| SMILES | C1=CC=C(C=C1)C#CC(=O)C2=CC(=CC=C2)[N+](=O)[O-] | |
| InChIKey | JODIUOIVYGKAJH-UHFFFAOYSA-N |
MLS000532223 is a selective inhibitor of Rho family GTPases that acts by blocking GTP binding to target GTPases. Inhibition of Rho family GTPase signaling disrupts downstream actin cytoskeleton remodeling, cell morphology, cell migration, and invasive cellular phenotypes. These regulatory pathways play central roles in modulating cellular motility, cell adhesion, and intracellular trafficking processes. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(199.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.