CAS No. 1228960-69-7

Batch: Purity:99.74
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MLN0905 Chemical Structure
Chemical Structure
Check the MLN0905 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
CAS Number 1228960-69-7
Molecular Formula

C24H25F3N6S
Molecular Weight (MW) 486.56
SMILES CC1=C(C=C(C=N1)CCCN(C)C)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)C(F)(F)F
InChIKey CODBZFJPKJDNDT-UHFFFAOYSA-N

Biological Activity

MLN0905 is a potent inhibitor of Polo-like kinase 1 (PLK1) with an IC50 of. Inhibition of PLK1 disrupts mitotic spindle formation and cell division, inducing G2/M phase arrest, accumulation of phosphohistone H3, and marked apoptosis in various cancer cell lines. Consequently, MLN0905 suppresses cellular proliferation and exhibits significant antitumor activity in xenograft tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49 mg/mL (100.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Duffey MO, et al. J Med Chem. 2012;55(1):197-208.

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Note: Technical data last updated: Sep 1, 2026.