ML385 is a specific and selective Nrf2 inhibitor. It affects Nrf2/HO-1 and Keap1/Nrf2/ARE signaling pathways by blocking Nrf2 nuclear translocation and transcriptional activity, effectively promoting oxidative stress, ferroptosis, and apoptosis.
ML385 Mechanism of Action: NRF2 Inhibition in Cancer Cell Research
ML385 MOA：Targeting NRF2/KEAP1 for Cancer Therapeutics and Chemoresistance