CAS No. 1991986-30-1

Batch: Purity:99.96
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ML364 Chemical Structure
Chemical Structure
Check the ML364 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(4-methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide
CAS Number 1991986-30-1
Molecular Formula

C24H18F3N3O3S2
Molecular Weight (MW) 517.54
SMILES CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CC(=C2)C(F)(F)F)C(=O)NC3=NC(=CS3)C4=CC=CC=C4
InChIKey QZUGMNXETPARLI-UHFFFAOYSA-N

Biological Activity

ML364 is a selective small-molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM. By inhibiting USP2 enzymatic activity, ML364 disrupts the deubiquitination and stabilization of downstream target proteins, promoting the degradation of cyclin D1. Consequently, ML364 impairs cell cycle progression and inhibits cancer cell proliferation, demonstrating potential for targeting ubiquitin-mediated oncogenic pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (115.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] ChemMedChem. 2016;11(11):1110-1113.

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Note: Technical data last updated: Sep 1, 2026.