CAS No. 1532593-30-8

Batch: Purity:99.98
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ML355 Chemical Structure
Chemical Structure
Check the ML355 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(1,3-benzothiazol-2-yl)-4-[(2-hydroxy-3-methoxyphenyl)methylamino]benzenesulfonamide
CAS Number 1532593-30-8
Molecular Formula

C21H19N3O4S2
Molecular Weight (MW) 441.52
SMILES COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
InChIKey OWHBVKBNNRYMIN-UHFFFAOYSA-N

Ordering Information

Biological Activity

ML355 is a potent small-molecule inhibitor targeting human 12-lipoxygenase (12-LOX) with high selectivity over related lipoxygenases and cyclooxygenases. By blocking 12-LOX enzymatic activity, ML355 impairs arachidonic acid metabolism and reduces downstream eicosanoid synthesis. This targeted inhibition modulates key cellular pathways involved in platelet activation, thrombosis, and inflammatory responses, serving as a valuable probe for investigating lipid signaling mechanisms. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.