CAS No. 847163-28-4

Batch: Purity:99.26
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ML351 Chemical Structure
Chemical Structure
Check the ML351 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile
CAS Number 847163-28-4
Molecular Formula

C15H11N3O
Molecular Weight (MW) 249.27
SMILES CNC1=C(N=C(O1)C2=CC=CC3=CC=CC=C23)C#N
InChIKey DYXYXTDIFMDJIR-UHFFFAOYSA-N

Ordering Information

Biological Activity

ML351 is a selective inhibitor of human 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 200 nM. By suppressing 15-LOX-1 catalytic activity, it selectively blocks enzymatic lipid peroxidation and modulates arachidonic acid metabolism pathways. Consequently, ML351 mitigates cellular oxidative stress, prevents reactive oxygen species accumulation, and protects neuronal cells from glutamate-induced toxicity and oxidative cell death. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (200.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.