CAS No. 890819-86-0
Batch:
Purity:99.48
Chemical Structure
Check the
ML349
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5,5-dioxo-4H-thieno[3,2-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone | |
|---|---|---|
| CAS Number | 890819-86-0 | |
| Molecular Formula |
C23H22N2O4S2 |
|
| Molecular Weight (MW) | 454.56 | |
| InChIKey | YVIJPELUPZUEJX-UHFFFAOYSA-N |
ML349 is a potent and selective inhibitor of acyl protein thioesterase 2 (APT2) with a Ki of 120 nM and an IC50 of 144 nM. By selectively blocking APT2-mediated depalmitoylation, ML349 disrupts dynamic S-acylation cycles and downstream target trafficking. Consequently, APT2 inhibition by ML349 impairs oncogenic signal transduction, leading to reduced cell proliferation in MCF10A and Snail-overexpressing cell lines.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(65.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.