CAS No. 100872-83-1

Batch: Purity:99.59
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ML346 Chemical Structure
Chemical Structure
Check the ML346 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione
CAS Number 100872-83-1
Molecular Formula

C14H12N2O4
Molecular Weight (MW) 272.26
SMILES COC1=CC=C(C=C1)C=CC=C2C(=O)NC(=O)NC2=O
InChIKey IXYLVJHFJKDHRM-NSCUHMNNSA-N

Biological Activity

ML346 is a heat shock protein 70 (Hsp70) activator and novel modulator of proteostasis for protein conformational diseases. The compound selectively enhances heat shock response signaling, leading to the upregulation of molecular chaperones including Hsp70. This selective activation promotes proper chaperone-mediated protein folding, prevents protein misfolding and toxic aggregate accumulation, and maintains cellular proteome homeostasis under conditions of proteotoxic stress. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 27 mg/mL (99.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Balch WE, et al. Science. 2008;319(5865):916-9.

[2] Muchowski PJ, et al. Nat Rev Neurosci. 2005;6(1):11-22.

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Note: Technical data last updated: Sep 1, 2026.