CAS No. 1432500-66-7
Batch:
Purity:97.90
Chemical Structure
Check the
ML334
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1432500-66-7 | |
|---|---|---|
| Molecular Formula |
C26H26N2O5 |
|
| Molecular Weight (MW) | 446.50 |
ML334 is a cell-permeable activator of NRF2 that disrupts the Keap1-NRF2 protein-protein interaction by binding to the Keap1 Kelch domain (Kd 1 μM). Disruption of this complex prevents Keap1-mediated degradation of NRF2, promoting its nuclear translocation and driving the transcription of downstream antioxidant response element genes to enhance cellular cytoprotection against oxidative stress. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.