CAS No. 1883510-31-3
Batch:
Purity:99.61
Chemical Structure
Check the
ML327
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[(2-oxo-1H-pyridine-3-carbonyl)amino]propyl]-5-phenyl-1,2-oxazole-3-carboxamide | |
|---|---|---|
| CAS Number | 1883510-31-3 | |
| Molecular Formula |
C19H18N4O4 |
|
| Molecular Weight (MW) | 366.37 | |
| SMILES | C1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCNC(=O)C3=CC=CNC3=O | |
| InChIKey | NNNDNXLMQAPQQQ-UHFFFAOYSA-N |
ML327 is an isoxazole small-molecule inhibitor that restores E-cadherin expression with an EC50 of 1.0 μM in cell-based assays. By derepressing E-cadherin and blocking MYC expression, ML327 targets key epithelial-to-mesenchymal transition signaling pathways. Through these downstream cellular mechanisms, the compound effectively promotes epithelial differentiation, induces apoptosis, and suppresses tumor formation in neuroblastoma cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(136.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.