CAS No. 1572414-83-5
Batch:
Purity:99.97
Chemical Structure
Check the
ML323
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 1572414-83-5 | |
| Molecular Formula |
C23H24N6 |
|
| Molecular Weight (MW) | 384.48 | |
| SMILES | CC1=CN=C(N=C1NCC2=CC=C(C=C2)N3C=CN=N3)C4=CC=CC=C4C(C)C | |
| InChIKey | VUIRVWPJNKZOSS-UHFFFAOYSA-N |
ML323 is a potent and selective inhibitor of the USP1/UAF1 deubiquitinase complex with an IC50 of. Inhibition of USP1/UAF1 by ML323 promotes the monoubiquitination of key DNA repair proteins, including FANCD2 and PCNA, thereby disrupting the Fanconi anemia pathway and translesion synthesis. Consequently, ML323 impairs DNA damage response mechanisms and sensitizes cancer cells to DNA-damaging chemotherapeutics such as cisplatin. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(197.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 38 mg/mL |
| Water | Insoluble |
| DMSO |
76 mg/mL
(197.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 76 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.