CAS No. 1404437-62-2
Batch:
Purity:99.97
Chemical Structure
Check the
ML281
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-(3-oxo-4H-quinoxalin-2-yl)-4-propan-2-ylphenyl]thiophene-2-carboxamide | |
|---|---|---|
| CAS Number | 1404437-62-2 | |
| Molecular Formula |
C22H19N3O2S |
|
| Molecular Weight (MW) | 389.47 | |
| SMILES | CC(C)C1=CC(=C(C=C1)NC(=O)C2=CC=CS2)C3=NC4=CC=CC=C4NC3=O | |
| InChIKey | HWOYIOLMBQSTQS-UHFFFAOYSA-N |
ML281 functions as a potent small-molecule inhibitor of serine/threonine kinase 33 (STK33). Targeting STK33 impairs downstream survival signaling pathways crucial for maintaining viability in oncogenic KRAS-driven malignancies. Consequently, pharmacological inhibition of STK33 displays selective toxicity toward KRAS-dependent cancer cell lines while sparing KRAS-independent cells, offering a targeted therapeutic strategy for KRAS-mutant tumors. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.