CAS No. 1401242-74-7
Batch:
Purity:99.76
Chemical Structure
Check the
ML277
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide | |
|---|---|---|
| CAS Number | 1401242-74-7 | |
| Molecular Formula |
C23H25N3O4S2 |
|
| Molecular Weight (MW) | 471.59 | |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2C(=O)NC3=NC(=CS3)C4=CC=C(C=C4)OC | |
| InChIKey | OXQNLLVUVDAEHC-OAQYLSRUSA-N |
ML277 is a potent activator of KCNQ1 channels that exhibits >100-fold selectivity over KCNQ2 and KCNQ4. By selectively enhancing KCNQ1-mediated potassium currents, ML277 augments the slow delayed rectifier potassium current (IKs). This activation promotes membrane hyperpolarization and shortens action potential duration in cardiac myocytes, modulating repolarization dynamics in electrophysiological pathways.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.