CAS No. 1346233-68-8
Batch:
Purity:98.66
Chemical Structure
Check the
ML218
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3,5-dichloro-N-[[(1R,5S)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]benzamide | |
|---|---|---|
| CAS Number | 1346233-68-8 | |
| Molecular Formula |
C19H26Cl2N2O |
|
| Molecular Weight (MW) | 369.33 | |
| InChIKey | GSJIGYLGKSBYBC-ALOPSCKCSA-N |
Biological Activity
ML218 is a potent and orally active T-type Ca²⁺ channel inhibitor that targets Cav3.2 (IC50 310 nM) and Cav3.3 (IC50 270 nM), as well as Cav3.1. By blocking voltage-gated calcium influx, ML218 modulates neuronal excitability and suppresses burst activity in subthalamic nucleus neurons. These cellular effects disrupt abnormal firing patterns within central neural circuits, highlighting its function in attenuating hyper-excitable neuronal pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
74 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.