CAS No. 489402-47-3
Batch:
Purity:99.91
Chemical Structure
Check the
ML213
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 489402-47-3 | |
|---|---|---|
| Molecular Formula |
C17H23NO
|
|
| Molecular Weight (MW) | 257.37 | |
| SMILES | CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C |
ML213 is a selective potassium channel opener targeting KCNQ2 (Kv7.2, EC50 = 230 nM) and KCNQ4 (Kv7.4, EC50 = 510 nM). By augmenting M-currents mediated by Kv7 channels, ML213 enhances membrane hyperpolarization and reduces neuronal hyperexcitability. This activation modulates signaling across neuronal circuits, suppressing repetitive action potential firing and demonstrating protective activity in models of epilepsy and pain disorders.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
25 mg/mL
(97.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
| DMSO |
25 mg/mL
(97.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.