CAS No. 5465-86-1
Batch:
Purity:99.93
Chemical Structure
Check the
ML204
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-2-piperidin-1-ylquinoline | |
|---|---|---|
| CAS Number | 5465-86-1 | |
| Molecular Formula |
C15H18N2 |
|
| Molecular Weight (MW) | 226.32 | |
| SMILES | CC1=CC(=NC2=CC=CC=C12)N3CCCCC3 | |
| InChIKey | USYRQXDHKXGTCK-UHFFFAOYSA-N |
ML204 is a potent and selective transient receptor potential canonical 4 (TRPC4) channel inhibitor, exhibiting IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. By blocking TRPC4-mediated calcium influx, ML204 disrupts downstream calcium-dependent signaling pathways and inhibits TRPC4 channel currents, exhibiting selectivity within the TRPC subfamily and over other non-TRP channels. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
45 mg/mL
(198.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 45 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.