CAS No. 1417700-13-0
Batch:
Purity:99.85
Chemical Structure
Check the
ML188
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(1R)-2-(tert-butylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide | |
|---|---|---|
| CAS Number | 1417700-13-0 | |
| Molecular Formula |
C26H31N3O3 |
|
| Molecular Weight (MW) | 433.54 | |
| SMILES | CC(C)(C)C1=CC=C(C=C1)N(C(C2=CN=CC=C2)C(=O)NC(C)(C)C)C(=O)C3=CC=CO3 | |
| InChIKey | JXGIYKRRPGCLFV-JOCHJYFZSA-N |
ML188 is a selective, non-covalent inhibitor of SARS-CoV 3CLpro. By specifically targeting the viral main protease 3CLpro, ML188 inhibits the proteolytic cleavage of overlapping replicase polyproteins into functional non-structural proteins. This block in polyprotein maturation impairs assembly of the viral replication-transcription complex, ultimately suppressing coronavirus replication and downstream viral propagation, thereby demonstrating broad cellular antiviral activity. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(200.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.