CAS No. 1035072-16-2

Batch: Purity:99.69
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ML162 Chemical Structure
Chemical Structure
Check the ML162 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1035072-16-2
Molecular Formula

C23H22Cl2N2O3S
Molecular Weight (MW) 477.40
SMILES COC1=C(Cl)C=C(C=C1)N(C(C(=O)NCCC2=CC=CC=C2)C3=CC=CS3)C(=O)CCl

Biological Activity

ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX4). By inhibiting GPX4 activity, ML162 impairs the cellular reduction of lipid hydroperoxides, leading to the toxic accumulation of lipid reactive oxygen species (ROS). This disruption of lipid peroxide homeostasis selectively triggers ferroptosis, an iron-dependent form of non-apoptotic cell death in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 13 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Yang WS, et al. Cell. 2014;156(1-2):317-331.

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Note: Technical data last updated: Sep 1, 2026.